Evidence map›Paper›PMID 24900762›Full record

ArticleACS medicinal chemistry letters2013

Inhibitors of tick-borne flavivirus reproduction from structure-based virtual screening.

Dmitry I Osolodkin, Liubov I Kozlovskaya, Evgenia V Dueva, Victor V Dotsenko, Yulia V Rogova, Konstantin A Frolov, Sergey G Krivokolysko, Ekaterina G Romanova, Alexey S Morozov, Galina G Karganova and 3 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
5.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 82 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. 3-[International journal of molecular sciences · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Enhanced taxonomy annotation of antiviral activity data from ChEMBL.Database : the journal of biological databases and curation · 2019
    Article
  9. Review
  10. A Roadmap for Tick-Borne Flavivirus Research in the "Omics" Era.Frontiers in cellular and infection microbiology · 2017
    Review
  11. Nucleoside inhibitors of tick-borne encephalitis virus.Antimicrobial agents and chemotherapy · 2015
    Article
  12. Spectrum of antiviral activity of 4-aminopyrimidineAntiviral chemistry & chemotherapy
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Dmitry I OsolodkinDepartment of Chemistry, Lomonosov Moscow State University , Moscow 119991, Russia ; FSBI Chumakov Institute of Poliomyelitis and Viral Encephalitides RAMS , Moscow 142782, Russia ; iSCALARE Laboratory, Moscow Institute of Physics and Technology , Dolgoprudny 141700, Russia.
Liubov I KozlovskayaFSBI Chumakov Institute of Poliomyelitis and Viral Encephalitides RAMS , Moscow 142782, Russia.
Evgenia V DuevaDepartment of Chemistry, Lomonosov Moscow State University , Moscow 119991, Russia ; FSBI Chumakov Institute of Poliomyelitis and Viral Encephalitides RAMS , Moscow 142782, Russia ; iSCALARE Laboratory, Moscow Institute of Physics and Technology , Dolgoprudny 141700, Russia.
Victor V DotsenkoChemEx Laboratory, Vladimir Dal' East Ukrainian National University , Lugansk 91034, Ukraine.
Yulia V RogovaFSBI Chumakov Institute of Poliomyelitis and Viral Encephalitides RAMS , Moscow 142782, Russia.
Konstantin A FrolovChemEx Laboratory, Vladimir Dal' East Ukrainian National University , Lugansk 91034, Ukraine.
Sergey G KrivokolyskoChemEx Laboratory, Vladimir Dal' East Ukrainian National University , Lugansk 91034, Ukraine.
Ekaterina G RomanovaDepartment of Chemistry, Lomonosov Moscow State University , Moscow 119991, Russia.
Alexey S MorozovDepartment of Chemistry, Lomonosov Moscow State University , Moscow 119991, Russia.
Galina G KarganovaFSBI Chumakov Institute of Poliomyelitis and Viral Encephalitides RAMS , Moscow 142782, Russia ; Department of Biology, Lomonosov Moscow State University , Moscow 119991, Russia.
Vladimir A PalyulinDepartment of Chemistry, Lomonosov Moscow State University , Moscow 119991, Russia ; iSCALARE Laboratory, Moscow Institute of Physics and Technology , Dolgoprudny 141700, Russia.
Vladimir M PentkovskiiSCALARE Laboratory, Moscow Institute of Physics and Technology , Dolgoprudny 141700, Russia.
Nikolay S ZefirovDepartment of Chemistry, Lomonosov Moscow State University , Moscow 119991, Russia ; iSCALARE Laboratory, Moscow Institute of Physics and Technology , Dolgoprudny 141700, Russia.
Chumakov Institute of Poliomyelitis and Viral Encephalitides · RULomonosov Moscow State University · RUMoscow Institute of Physics and Technology · RUVolodymyr Dahl East Ukrainian National University · UA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Flaviviruses form a large family of enveloped viruses affecting millions of people over the world. To date, no specific therapy was suggested for the infected people, making the treatment exclusively symptomatic. Several attempts were performed earlier for the design of fusion inhibitors for mosquito-borne flaviviruses, whereas for the tick-borne flaviviruses such design had not been performed. We have constructed homology models of envelope glycoproteins of tick-transmitted flaviviruses with the detergent binding pocket in the open state. Molecular docking of substituted 1,4-dihydropyridines and pyrido[2,1-b][1,3,5]thiadiazines was made against these models, and 89 hits were selected for the in vitro experimental evaluation. Seventeen compounds showed significant inhibition against tick-borne encephalitis virus, Powassan virus, or Omsk hemorrhagic fever virus in the 50% plaque reduction test in PEK cells. These compounds identified through rational design are the first ones possessing reproduction inhibition activity against tick-borne flaviviruses.

Indexed as

1,4-dihydropyridinesAntiviral compoundsflaviviruspyrido[2,1-b][1,3,5]thiadiazines

Identifiers

PMID24900762
PMCPMC4027560
OpenAlexW2014682115

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.