ArticleACS medicinal chemistry letters2013
Contribution of Cage-Shaped Structure of Physalins to Their Mode of Action in Inhibition of NF-κB Activation.
Article in ACS medicinal chemistry letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Asymmetric multi-component trifunctionalization reactions with α-Halo Rh-carbenes.Nature communications · 2025Article
- Production and Structural Diversification of Withanolides by Aeroponic Cultivation of Plants of Solanaceae: Cytotoxic and Other Withanolides from Aeroponically GrownMolecules (Basel, Switzerland) · 2022Article
- Natural Products fromMolecules (Basel, Switzerland) · 2022Review
- Isolation and characterisation of irinans, androstane-type withanolides fromBeilstein journal of organic chemistry · 2019Article
- Withanolides from Aeroponically Grown Physalis peruviana and Their Selective Cytotoxicity to Prostate Cancer and Renal Carcinoma Cells.Journal of natural products · 2017Article
- Synthesis of the Right-Side Structure of Type B Physalins.Israel journal of chemistry · 2017Article
- Comparative Characterization of the Leaf Tissue ofFrontiers in plant science · 2016Article
- Natural Withanolides in the Treatment of Chronic Diseases.Advances in experimental medicine and biologyReview
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Authors and funding
9 authors.
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Abstract
A library of oxygenated natural steroids, including physalins, withanolides, and perulactones, coupled with the synthetic cage-shaped right-side structure of type B physalins, was constructed. SAR studies for inhibition of NF-κB activation showed the importance of both the B-ring and the oxygenated right-side partial structure. The 5β,6β-epoxy derivatives of both physalins and withanolides showed similar profiles of inhibition of NF-κB activation and appeared to act on NF-κB signaling via inhibition of phosphorylation and degradation of IκBα. In contrast, type B physalins with C5-C6 olefin functionality inhibited nuclear translocation and DNA binding of RelA/p50 protein dimer, which lie downstream of IκBα degradation, although withanolides having the same AB-ring functionality did not. These results indicated that the right-side partial structure of these steroids influences their mode of action.
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