ArticleACS medicinal chemistry letters2013
PiB-Conjugated, Metal-Based Imaging Probes: Multimodal Approaches for the Visualization of β-Amyloid Plaques.
Article in ACS medicinal chemistry letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 54 citations in OpenAlex.
- Molecular design of MRI probes for targeting amyloid-β species: fromTheranostics · 2026Review
- Interaction of MRI Contrast Agent [Gd(DOTA)]Inorganic chemistry · 2024Article
- Molecular Design of Magnetic Resonance Imaging Agents Binding to Amyloid Deposits.International journal of molecular sciences · 2023Review
- Near-infrared fluorescence lifetime imaging of amyloid-β aggregates and tau fibrils through the intact skull of mice.Nature biomedical engineering · 2023Article
- Article
- Development of an MRI contrast agent for both detection and inhibition of the amyloid-β fibrillation process.RSC advances · 2022Article
- Metals in Imaging of Alzheimer's Disease.International journal of molecular sciences · 2020Review
- Functionalised Carbon Nanotubes Enhance Brain Delivery of Amyloid-Targeting Pittsburgh Compound B (PiB)-Derived Ligands.Nanotheranostics · 2018Article
- Gd-nanoparticles functionalization with specific peptides for ß-amyloid plaques targeting.Journal of nanobiotechnology · 2016Article
- Gallium-68 Complexes Conjugated to Pittsburgh Compound B: Radiolabeling and Biological Evaluation.Molecular imaging and biology · 2016Article
- Associating a negatively charged GdDOTA-derivative to the Pittsburgh compound B for targeting Aβ amyloid aggregates.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2016Article
- BACE1 in the retina: a sensitive biomarker for monitoring early pathological changes in Alzheimer's disease.Neural regeneration research · 2016Article
- Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer׳s disease.Acta pharmaceutica Sinica. B · 2015Review
- Gd(3+) complexes conjugated to Pittsburgh compound B: potential MRI markers of β-amyloid plaques.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2014Article
- Potential applications of magnetic particles to detect and treat Alzheimer's disease.Nanoscale research letters · 2014Article
- Advances in nanoprobes for molecular MRI of Alzheimer's disease.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In an effort toward the visualization of β-amyloid plaques by in vivo imaging techniques, we have conjugated an optimized derivative of the Pittsburgh compound B (PiB), a well-established marker of Aβ plaques, to DO3A-monoamide that is capable of forming stable, noncharged complexes with different trivalent metal ions including Gd(3+) for MRI and (111)In(3+) for SPECT applications. Proton relaxivity measurements evidenced binding of Gd(DO3A-PiB) to the amyloid peptide Aβ1-40 and to human serum albumin, resulting in a two- and four-fold relaxivity increase, respectively. Ex vivo immunohistochemical studies showed that the DO3A-PiB complexes selectively target Aβ plaques on Alzheimer's disease human brain tissue. Ex vivo biodistribution data obtained for the (111)In-analogue pointed to a moderate blood-brain barrier (BBB) penetration in adult male Swiss mice (without amyloid deposits) with 0.36% ID/g in the cortex at 2 min postinjection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.