Evidence map›Paper›PMID 24900586›Full record

ArticleACS medicinal chemistry letters2013

Non-cross-bridged tetraazamacrocyclic chelator for stable (64)cu-based radiopharmaceuticals.

Ajit V Dale, Darpan N Pandya, Jung Young Kim, Hochun Lee, Yeong Su Ha, Nikunj Bhatt, Jonghee Kim, Jeong Ju Seo, Woonghee Lee, Sung Hong Kim and 3 more

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. TowardInorganic chemistry · 2023
    Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ajit V DaleDepartment of Molecular Medicine, Kyungpook National University School of Medicine , Daegu 700-422, South Korea.
Darpan N PandyaDepartment of Molecular Medicine, Kyungpook National University School of Medicine , Daegu 700-422, South Korea.
Jung Young KimMolecular Imaging Research Centre, Korea Institute of Radiological and Medical Sciences , Seoul 139-706, South Korea.
Hochun LeeDepartment of Energy Systems Engineering, Daegu Gyeongbuk Institute of Science & Technology, Daegu 711-873, South Korea.
Yeong Su HaDepartment of Molecular Medicine, Kyungpook National University School of Medicine , Daegu 700-422, South Korea.
Nikunj BhattDepartment of Molecular Medicine, Kyungpook National University School of Medicine , Daegu 700-422, South Korea.
Jonghee KimDepartment of Molecular Medicine, Kyungpook National University School of Medicine , Daegu 700-422, South Korea.
Jeong Ju SeoDepartment of Biomedical Science and Clinical Trial Center, Kyungpook National University Graduates School and Hospital , Daegu, South Korea.
Woonghee LeeDepartment of Molecular Medicine, Kyungpook National University School of Medicine , Daegu 700-422, South Korea.
Sung Hong KimAnalysis Research Division, Daegu Center, Korea Basic Science Institute , Daegu 702-701, South Korea.
Young-Ran YoonDepartment of Biomedical Science and Clinical Trial Center, Kyungpook National University Graduates School and Hospital , Daegu, South Korea.
Gwang Il AnMolecular Imaging Research Centre, Korea Institute of Radiological and Medical Sciences , Seoul 139-706, South Korea.
Jeongsoo YooDepartment of Molecular Medicine, Kyungpook National University School of Medicine , Daegu 700-422, South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

N-mono/dimethylated TE2A tetraazamacrocycles (MM-TE2A and DM-TE2A) were synthesized in high yields. Both Cu-MM/DM-TE2A complexes showed increased kinetic stability compared to that of Cu-TE2A, whereas Cu-DM-TE2A showed even higher in vitro stability than that of Cu-ECB-TE2A. MM-TE2A and DM-TE2A were quantitatively radiolabeled with (64)Cu ions and showed rapid clearance from the body to emerge as a potential efficient bifunctional chelator.

Indexed as

Bifunctional chelatorcopper compleximaging agentradiopharmaceutical

Identifiers

PMID24900586
PMCPMC4027512

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.