ArticleACS medicinal chemistry letters2012
Lipidated peptidomimetics with improved antimicrobial activity.
Article in ACS medicinal chemistry letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Short, Lipidated Dendrimeric γ-AApeptides as New Antimicrobial Peptidomimetics.International journal of molecular sciences · 2023Article
- Antimicrobial Peptide Mimics for Clinical Use: Does Size Matter?Frontiers in immunology · 2022Review
- Discovery, Optimization, and Clinical Application of Natural Antimicrobial Peptides.Biomedicines · 2021Review
- Antimicrobial Peptides and Proteins: From Nature's Reservoir to the Laboratory and Beyond.Frontiers in chemistry · 2021Review
- Novel temporin L antimicrobial peptides: promoting self-assembling by lipidic tags to tackle superbugs.Journal of enzyme inhibition and medicinal chemistry · 2020Article
- Dimeric γ-AApeptides With Potent and Selective Antibacterial Activity.Frontiers in chemistry · 2020Article
- Small antibacterial molecules highly active against drug-resistantMedChemComm · 2019Article
- Developments with investigating descriptors for antimicrobial AApeptides and their derivatives.Expert opinion on drug discovery · 2018Review
- Lipidated α/α-AA heterogeneous peptides as antimicrobial agents.European journal of medicinal chemistry · 2018Article
- Membrane-Active Hydantoin Derivatives as Antibiotic Agents.Journal of medicinal chemistry · 2017Article
- Advances in Development of Antimicrobial Peptidomimetics as Potential Drugs.Molecules (Basel, Switzerland) · 2017Review
- Structure and Function of AApeptides.Biochemistry · 2017Review
- Polycarbonates with Potent and Selective Antimicrobial Activity toward Gram-Positive Bacteria.Biomacromolecules · 2017Article
- Antimicrobial AApeptides.Current topics in medicinal chemistry · 2017Review
- Tuning Liposome Membrane Permeability by Competitive Peptide Dimerization and Partitioning-Folding Interactions Regulated by Proteolytic Activity.Scientific reports · 2016Article
- Toward Hemocompatible Self-assembling Antimicrobial Nanofibers: Understanding the Synergistic Effect of Supramolecular Structure and PEGylation on Hemocompatibility.RSC advances · 2016Article
- Tackling vancomycin-resistant bacteria with 'lipophilic-vancomycin-carbohydrate conjugates'.The Journal of antibiotics · 2015Article
- Synthesis of antibacterial 1,3-diyne-linked peptoids from an Ugi-4CR/Glaser coupling approach.Beilstein journal of organic chemistry · 2015Article
- Short antimicrobial lipo-α/γ-AA hybrid peptides.Chembiochem : a European journal of chemical biology · 2014Article
- The development of antimicrobial a-AApeptides that suppress proinflammatory immune responses.Chembiochem : a European journal of chemical biology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report a series of lipidated α-AApeptides that mimic the structure and function of natural antimicrobial lipopeptides. Several short lipidated α-AApeptides show broad-spectrum activity against a range of clinically related Gram-positive and Gram-negative bacteria as well as fungus. Their antimicrobial activity and selectivity are comparable or even superior to the clinical candidate pexiganan as well as previously reported linear α-AApeptides. The further development of lipidated α-AApeptides will lead to a new class of antibiotics to combat drug resistance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.