ArticleACS medicinal chemistry letters2012
Synthesis and Anti-influenza A Virus Activity of 2,2-Dialkylamantadines and Related Compounds.
Article in ACS medicinal chemistry letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Adamantane-based inhibitors of the influenza A M2 proton channel: structure-based design, biological evaluation, and synthetic approaches.RSC medicinal chemistry · 2026Review
- Molecular biophysics and inhibition mechanism of influenza virus A M2 viroporin by adamantane-based drugs - Challenges in designing antiviral agents.Journal of structural biology: X · 2025Article
- Spatial arrangements of cyclodextrin host-guest complexes in solution studied byBeilstein journal of organic chemistry · 2024Article
- Synthesis of 1,2-Disubstituted Adamantane Derivatives by Construction of the Adamantane Framework.Molecules (Basel, Switzerland) · 2023Review
- Annulated carbamates are precursors for the ring contraction of the adamantane framework.RSC advances · 2022Article
- Adamantane-Substituted Purines and Their β-Cyclodextrin Complexes: Synthesis and Biological Activity.International journal of molecular sciences · 2021Article
- Chemical Probes for Blocking of Influenza A M2 Wild-type and S31N Channels.ACS chemical biology · 2020Article
- Binding and Proton Blockage by Amantadine Variants of the Influenza M2Journal of medicinal chemistry · 2017Article
- Investigation of a recent rise of dual amantadine-resistance mutations in the influenza A M2 sequence.BMC genetics · 2015Article
- Azapropellanes with anti-influenza a virus activity.ACS medicinal chemistry letters · 2014Article
- Easily accessible polycyclic amines that inhibit the wild-type and amantadine-resistant mutants of the M2 channel of influenza A virus.Journal of medicinal chemistry · 2014Article
- Aminoadamantanes with persistent in vitro efficacy against H1N1 (2009) influenza A.Journal of medicinal chemistry · 2014Article
- 3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant.Journal of medicinal chemistry · 2013Article
- Role of the viral hemagglutinin in the anti-influenza virus activity of newly synthesized polycyclic amine compounds.Antiviral research · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The synthesis of several 2,2-dialkyladamantyl-1-amines through the combination of a Ritter reaction with a Wagner-Meerwein rearrangement from noradamantane alcohols is reported. Several of the novel amines displayed low micromolar activities against several H1N1 influenza virus strains, including the amantadine-resistant A/PuertoRico/8/34 strain. Most of the compounds did not show cytotoxicity for MDCK cells.
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