Evidence map›Paper›PMID 24900369›Full record

ArticleACS medicinal chemistry letters2012

Sphingolipid analogues inhibit development of malaria parasites.

Esmeralda V S Meyer, Jason J Holt, Kathryn R Girard, Mark T Ballie, Anatoliy S Bushnev, Stacey Lapp, David S Menaldino, Richard F Arrendale, G Prabhakar Reddy, Taylor J Evers and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. FASEB bioAdvances · 2026
    Article
  2. Article
  3. Article
  4. Revisiting Drug Development Against the Neglected Tropical Disease, Amebiasis.Frontiers in cellular and infection microbiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Esmeralda V S MeyerEmory Vaccine Center and Yerkes National Primate Research Center, Emory University , Atlanta, Georgia 30329, United States.
Jason J HoltEmory Institute for Drug Discovery (EIDD) , 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Kathryn R GirardEmory Vaccine Center and Yerkes National Primate Research Center, Emory University , Atlanta, Georgia 30329, United States.
Mark T BallieDepartment of Chemistry, Emory University , 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Anatoliy S BushnevDepartment of Chemistry, Emory University , 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Stacey LappEmory Vaccine Center and Yerkes National Primate Research Center, Emory University , Atlanta, Georgia 30329, United States.
David S MenaldinoEmory Institute for Drug Discovery (EIDD) , 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Richard F ArrendaleEmory Institute for Drug Discovery (EIDD) , 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
G Prabhakar ReddyEmory Institute for Drug Discovery (EIDD) , 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Taylor J EversEmory Institute for Drug Discovery (EIDD) , 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Randy B HowardEmory Institute for Drug Discovery (EIDD) , 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Deborah G CulverEmory Institute for Drug Discovery (EIDD) , 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Dennis C LiottaDepartment of Chemistry, Emory University , 1515 Dickey Drive, Atlanta, Georgia 30322, United States ; Emory Institute for Drug Discovery (EIDD) , 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Mary R GalinskiEmory Vaccine Center and Yerkes National Primate Research Center, Emory University , Atlanta, Georgia 30329, United States ; Emory University School of Medicine, Department of Medicine, Division of Infectious Diseases, Emory University , Atlanta, Georgia 30322, United States.
Michael G NatchusEmory Institute for Drug Discovery (EIDD) , 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Atlanta VA Medical Center · USEmory University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plasmodium-infected erythrocytes have been shown to employ sphingolipids from both endogenous metabolism as well as existing host pools. Therapeutic agents that limit these supplies have thus emerged as intriguing, mechanistically distinct putative targets for the treatment of malaria infections. In an initial screen of our library of sphingolipid pathway modulators for efficacy against two strains of the predominant human malaria species Plasmodium falciparum and Plasmodium knowlesi, a series of orally available, 1-deoxysphingoid bases were found to possess promising in vitro antimalarial activity. To better understand the structural requirements that are necessary for this observed activity, a second series of modified analogues were prepared and evaluated. Initial pharmacokinetic assessments of key analogues were investigated to evaluate plasma and red blood cell concentrations in vivo.

Indexed as

antimalarialsdrugsEnigmolsmalariaPlasmodiumsphingolipids

Identifiers

PMID24900369
PMCPMC4025872
OpenAlexW2058636411

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.