ArticleACS medicinal chemistry letters2011
Sulfonate-containing thiiranes as selective gelatinase inhibitors.
Article in ACS medicinal chemistry letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 37 citations in OpenAlex.
- Epoxides: Small Rings to Play with under Asymmetric Organocatalysis.ACS organic & inorganic Au · 2022Review
- Demystifying the extracellular matrix and its proteolytic remodeling in the brain: structural and functional insights.Cellular and molecular life sciences : CMLS · 2019Review
- Targeting MMP-9 in Diabetic Foot Ulcers.Pharmaceuticals (Basel, Switzerland) · 2019Review
- Discovery of Mechanism-Based Inactivators for Human Pancreatic Carboxypeptidase A from a Focused Synthetic Library.ACS medicinal chemistry letters · 2017Article
- Acceleration of diabetic wound healing using a novel protease-anti-protease combination therapy.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Water-Soluble MMP-9 Inhibitor Reduces Lesion Volume after Severe Traumatic Brain Injury.ACS chemical neuroscience · 2015Article
- Water-soluble mmp-9 inhibitor prodrug generates active metabolites that cross the blood-brain barrier.ACS chemical neuroscience · 2013Article
- Extension of the CHARMM General Force Field to sulfonyl-containing compounds and its utility in biomolecular simulations.Journal of computational chemistry · 2012Article
- Structure-Activity Relationship for Thiirane-Based Gelatinase Inhibitors.ACS medicinal chemistry letters · 2012Article
- Detection of MMP-2 and MMP-9 activity in vivo with a triple-helical peptide optical probe.Bioconjugate chemistry · 2012Article
- Selective water-soluble gelatinase inhibitor prodrugs.Journal of medicinal chemistry · 2011Article
- Exploration of mild copper-mediated coupling of organotrifluoroborates in the synthesis of thiirane-based inhibitors of matrix metalloproteinases.Bioorganic & medicinal chemistry letters · 2011Article
- Role of matrix metalloproteinases and therapeutic benefits of their inhibition in spinal cord injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2011Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Matrix metalloproteinases (MMPs) are important zinc-dependent endopeptidases. Two members of this family of enzymes called gelatinases (MMP-2 and MMP-9) have been implicated in a number of human diseases, including cancer, neurological and cardiovascular diseases, and inflammation, to name a few. We describe in this report the preparation and evaluation of two structural types of thiirane inhibitors that show selectivity toward gelatinases. The biphenyl series targets both gelatinases, whereas the monophenyl analogues exhibit potent inhibition of only MMP-2. The latter structural type also exhibits improved water solubility and metabolic stability, both traits desirable for progress of these molecules forward in gelatinase-dependent animal models of disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.