ArticleNuclear medicine and molecular imaging2013
Parametric Cerebrovascular Reserve Images Using Acetazolamide (99m)Tc-HMPAO SPECT: A Feasibility Study of Quantitative Assessment.
Article in Nuclear medicine and molecular imaging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Toward Semiautomated Analysis of Cerebrovascular Reserve: Enhancing Objective Comparisons Using 99m Tc-HMPAO SPECT With Acetazolamide in Moyamoya.Neurosurgery · 2026Article
- Deep learning-based interpretation of basal/acetazolamide brain perfusion SPECT leveraging unstructured reading reports.European journal of nuclear medicine and molecular imaging · 2020Article
- Basal and Acetazolamide Brain Perfusion SPECT in Internal Carotid Artery Stenosis.Nuclear medicine and molecular imaging · 2020Review
- Imaging Diagnosis of Transient Ischemic Attack in Clinic and Traditional Chinese Medicine.BioMed research international · 2019Review
- The Current Status of SPECT or SPECT/CT in South Korea.Nuclear medicine and molecular imaging · 2017Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBasal/acetazolamide stress (99m)Tc-HMPAO single-photon emission computed tomography (SPECT) has been widely used for evaluation of hemodynamics; however, qualitative and subjective visual assessment of cerebrovascular reserve (CVR) has been performed in clinical settings. The aim of this study was to generate parametric CVR images and evaluate its feasibility of quantification.
methodsBasal/acetazolamide stress (99m)Tc-HMPAO SPECT data from 17 patients who underwent bypass surgery or percutaneous transluminal angioplasty were used. Spatial normalization was performed and parametric CVR images were generated using relative CVR (rCVR) of each voxel proportional to CVR of the whole brain. Binary parametric maps to show area of relatively reduced CVR were generated also using threshold of rCVR < 90 %. We calculated rCVR of internal carotid artery (ICA) using the parametric CVR images and probabilistic maps for ICA territory. Pre- and postprocedural parametric CVR images were obtained and quantitative rCVRs were compared. The rCVRs were evaluated according to visual grades for regional decreased CVR.
resultsPostprocedural rCVR obtained from parametric CVR images increased significantly from preprocedural rCVR. The rCVR was significantly correlated with visual grades of reduced CVR for each side of ICA territories.
conclusionsWe generated parametric CVR images for basal/acetazolamide stress (99m)Tc-HMPAO SPECT. As a quantitative measurement, rCVR obtained from the parametric image was feasibly assessed hemodynamic abnormalities with preserved anatomical information.
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