ReviewInternational journal of endocrinology2014
Paragangliomas/Pheochromocytomas: clinically oriented genetic testing.
Review in International journal of endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 79 citations in OpenAlex.
- Expanding the therapeutic horizon ofNagoya journal of medical science · 2025Review
- Anesthetic Management of Metastatic Paraganglioma With Spinal Metastases in a Comorbid Cardiovascular Patient.Cureus · 2025Article
- Case Report: A rare case of primary hepatic paraganglioma: a mimicker of hepatocellular carcinoma.Frontiers in oncology · 2025Article
- Case Report: Rare multisystem metastasis in head and neck paraganglioma withFrontiers in endocrinology · 2025Article
- Late Onset Malignant Metastatic Transformation of Benign Pheochromocytoma.Journal of community hospital internal medicine perspectives · 2025Article
- Von Hippel-Lindau disease with ocular and multiple systemic findings.BMJ case reports · 2024Article
- Article
- Differences between Patients with Sporadic and Familial Pheochromocytoma-Is It Possible to Avoid Genetic Testing in Certain Patients?Biomedicines · 2024Article
- Synchronous Carotid Body and Glomus Jugulare Tumors : A Case Report and Review of Literature.Journal of Korean Neurosurgical Society · 2024Article
- Case report: A rare DLST mutation in patient with metastatic pheochromocytoma: clinical implications and management challenges.Frontiers in oncology · 2024Article
- Metastatic paraganglioma.BMJ case reports · 2023Article
- Case Report: Aggressive neural crest tumors in a child with familial von Hippel Lindau syndrome associated with a germlineFrontiers in endocrinology · 2023Article
- MULTIPLE NEUROENDOCRINE NEOPLASIA IN A PATIENT WITH TYPE I NEUROFIBROMATOSIS (NF1): REPORT OF A NEW MUTATION (NF1, EXONS 2-30 DELETION) AND LITERATURE REVIEW.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2023Review
- Pheochromocytoma: A Case Report.Cureus · 2022Article
- RET T244I Germline Variant Mutation in a Patient with Pancreatic Paraganglioma and Primary Hyperparathyroidism.International journal of endocrinology and metabolism · 2022Article
- PGL4 syndrome in a patient with synchronous paraganglioma-pheochromocytoma.BMJ case reports · 2022Article
- Tumour detection and outcomes of surveillance screening in SDHB and SDHD pathogenic variant carriers.Endocrine connections · 2022Article
- Composite Paraganglioma of the Celiac Trunk: A Case Report and a Comprehensive Review of the Literature.Frontiers in surgery · 2022Review
- Diagnosis and Outcome of Cardiac Paragangliomas: A Retrospective Observational Cohort Study in China.Frontiers in cardiovascular medicine · 2021Article
- CytoJounal quiz case: Fine-needle aspiration of peripancreatic mass clinically mimicking a lymphoma.CytoJournal · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paragangliomas are rare neuroendocrine tumors that arise in the sympathetic or parasympathetic nervous system. Sympathetic paragangliomas are mainly found in the adrenal medulla (designated pheochromocytomas) but may also have a thoracic, abdominal, or pelvic localization. Parasympathetic paragangliomas are generally located at the head or neck. Knowledge concerning the familial forms of paragangliomas has greatly improved in recent years. Additionally to the genes involved in the classical syndromic forms: VHL gene (von Hippel-Lindau), RET gene (Multiple Endocrine Neoplasia type 2), and NF1 gene (Neurofibromatosis type 1), 10 novel genes have so far been implicated in the occurrence of paragangliomas/pheochromocytomas: SDHA, SDHB, SDHC, SDHD, SDHAF2, TMEM127, MAX, EGLN1, HIF2A, and KIF1B. It is currently accepted that about 35% of the paragangliomas cases are due to germline mutations in one of these genes. Furthermore, somatic mutations of RET, VHL, NF1, MAX, HIF2A, and H-RAS can also be detected. The identification of the mutation responsible for the paraganglioma/pheochromocytoma phenotype in a patient may be crucial in determining the treatment and allowing specific follow-up guidelines, ultimately leading to a better prognosis. Herein, we summarize the most relevant aspects regarding the genetics and clinical aspects of the syndromic and nonsyndromic forms of pheochromocytoma/paraganglioma aiming to provide an algorithm for genetic testing.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.