ArticleInternational journal of tryptophan research : IJTR2014
Tryptophan and kynurenic Acid may produce an amplified effect in central fatigue induced by chronic sleep disorder.
Article in International journal of tryptophan research : IJTR, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 27 citations in OpenAlex.
- High social jetlag in healthy youth: differences in tryptophan levels and regional gray matter volume.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Potential Treatment for ADHD Based on Recovery from Tryptophan-Induced Central Fatigue by Powerful Competitive Inhibition of L-System Amino Acid Transporter.International journal of tryptophan research : IJTR · 2026Article
- Neurochemical Insights into the Role of Tryptophan Metabolites and Kynurenine Pathway in Insomnia and its Psychological and Neurological Comorbidities.Molecular neurobiology · 2025Review
- Assessment of the Gut Microbiome in Patients with Coexisting Irritable Bowel Syndrome and Chronic Fatigue Syndrome.Nutrients · 2025Article
- Sex differences in reward-based operant conditioning performance and neurotransmitter changes following chronic sleep restriction stress in rats.Behavioral and brain functions : BBF · 2025Article
- Voltammetric determination of tryptophan at graphitic carbon nitride modified carbon paste electrode.Heliyon · 2023Article
- Article
- The relationship between central fatigue and Attention Deficit/Hyperactivity Disorder of the inattentive type.Neurochemical research · 2022Article
- Korean Red Ginseng Ameliorates Fatigue via Modulation of 5-HT and Corticosterone in a Sleep-Deprived Mouse Model.Nutrients · 2021Article
- Inflammation Disturbed the Tryptophan Catabolites in Hippocampus of Post-operative Fatigue Syndrome RatsFrontiers in neuroscience · 2021Article
- Acute sleep deprivation during pregnancy in rats: Rapid elevation of placental and fetal inflammation and kynurenic acid.Neurobiology of stress · 2020Article
- Potential Role of Neuroactive Tryptophan Metabolites in Central Fatigue: Establishment of the Fatigue Circuit.International journal of tryptophan research : IJTR · 2020Review
- Effects of Sleep Deprivation on the Tryptophan Metabolism.International journal of tryptophan research : IJTR · 2020Review
- A new inbred strain of Fawn-Hooded rats demonstrates mania-like behavioural and monoaminergic abnormalities.IBRO reports · 2019Article
- Tryptophan Metabolites in Irritable Bowel Syndrome: An Overnight Time-course Study.Journal of neurogastroenterology and motility · 2019Article
- Liver CEBPβ Modulates the Kynurenine Metabolism and Mediates the Motility for Hypoxia-Induced Central Fatigue in Mice.Frontiers in physiology · 2019Article
- Beneficial effect of compound essential oil inhalation on central fatigue.BMC complementary and alternative medicine · 2018Article
- A Rat Model of Central Fatigue Using a Modified Multiple Platform Method.Journal of visualized experiments : JoVE · 2018Article
- Sex Differences in Hippocampal Memory and Kynurenic Acid Formation Following Acute Sleep Deprivation in Rats.Scientific reports · 2018Article
- Kynurenine pathway is altered in patients with SLE and associated with severe fatigue.Lupus science & medicine · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tryptophan (TRP) and its neuroactive metabolite, kynurenic acid (KYNA), are thought to play key roles in central fatigue, but the specifics are still unknown. To clarify their roles in the brain, we developed a rat model of central fatigue induced by chronic sleep disorder (CFSD) by disturbing the sleep-wake cycle. Results showed that while 5-hydroxytryptamine (5-HT) concentration did not differ between control and CFSD groups, levels of TRP and KYNA in the CFSD group were about 2 and 5 times higher in the hypothalamus, and 2 and 3.5 times higher in the hippocampus, respectively. Moreover, CFSD-induced fatigue led to abnormal running performance (via treadmill test) and social interaction (via social-interaction test). These results support a TRP-KYNA hypothesis in central fatigue in which increased TRP concentration in the brain and subsequently synthesized KYNA may produce an amplified effect on central fatigue, with enhanced concentrations being a possible mechanism by which social-interaction deficits are generated.
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