ArticleClinical ophthalmology (Auckland, N.Z.)2014
Visual loss and optic nerve head swelling in thiamine deficiency without prolonged dietary deficiency.
Article in Clinical ophthalmology (Auckland, N.Z.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Micronutrient Deficiencies Presenting with Optic Disc Swelling Associated with or without Intracranial Hypertension: A Systematic Review.Nutrients · 2022Pooled it
- Article
- Article
- From vision loss to paralysis: a striking case of Wernicke's encephalopathy in pregnancy.Annals of medicine and surgery (2012) · 2025Article
- Swept-Source Optical Coherence Tomography in the Diagnosis and Monitoring of Optic Nerve Neuropathy in Patients with Wernicke's Encephalopathy Due to Hyperemesis Gravidarum.Journal of clinical medicine · 2025Review
- Article
- Xeropthalmia and optic neuropathy secondary to ARFID: a case report.Journal of eating disorders · 2024Article
- Optic Nerve Neuroprotection in Glaucoma: A Narrative Review.Journal of clinical medicine · 2024Review
- Wernicke Syndrome: Case Report and Literature Review of Contributing Factors-Can Malpractice Dynamics Be Identified?Journal of clinical medicine · 2024Review
- Ocular Manifestations of Wernicke's Encephalopathy in a Patient with Hyperemesis Gravidarum Complicating Pregnancy.Beyoglu eye journal · 2023Article
- Bilateral papilledema with vision loss due to post-COVID-19-induced thiamine deficiency: illustrative case.Journal of neurosurgery. Case lessons · 2022Article
- Thiamine supplementation holds neurocognitive benefits for breastfed infants during the first year of life.Annals of the New York Academy of Sciences · 2021Article
- Review
- Review
- Optic neuropathy in Wernicke encephalopathy: More than meets the eye?CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2020Article
- Neuro-ophthalmic Manifestations of Wernicke Encephalopathy.Eye and brain · 2020Review
- The effects of thiamine pyrophosphate on ethanol induced optic nerve damage.BMC pharmacology & toxicology · 2019Article
- Visual loss and optic neuropathy associated with Wernicke's encephalopathy in hyperemesis gravidarum.Journal of family medicine and primary care · 2019Article
- Treatment and Outcomes in Nutritional Optic Neuropathy.Current treatment options in neurology · 2019Review
- Visual Loss, Retinal Hemorrhages, and Optic Disc Edema Resulting From Thiamine Deficiency Following Bariatric Surgery Complicated by Prolonged Vomiting.Ochsner journal · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Visual loss due to optic neuropathy is a rare manifestation of thiamine deficiency. We report a case of a 39-year-old woman with a body mass index (BMI) of 29 kg/m(2) who developed visual loss and bilateral optic nerve head swelling after a short, self-limited gastrointestinal illness. She was disoriented and inattentive and had absent ankle jerk reflexes, diminished sensation in both legs below the knees, and marked truncal ataxia. Magnetic resonance imaging (MRI) showed increased T2-signal in the medial thalami and mammillary bodies. The serum thiamine level was 8 nmol/L (normal 8-30). The diagnosis of thiamine deficiency was made, and the patient's vision and neurologic symptoms improved significantly with intramuscular thiamine treatment. Thiamine deficiency can occur in the absence of an obvious predisposing factor such as alcoholism or low body weight. The clinician must be aware of the factors that govern vitamin availability and maintain a high index of suspicion to make the diagnosis in such cases.
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