Evidence map›Paper›PMID 24899776›Full record

ArticleBiology of sport2014

Blood flow restricted resistance training attenuates myostatin gene expression in a patient with inclusion body myositis.

A R Santos, M T Neves, B Gualano, G C Laurentino, A H Lancha, C Ugrinowitsch, F R Lima, M S Aoki

Registry-linked trialOpen access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology of sport, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04309227 (Comparison of Traditional High-Load Training With Low-Load Plus Blood Flow Restriction Training on Strength, Function, and Self-Reported Outcomes in Patients With Rheumatoid Disorders), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04309227 naterminatednot on this mapstarted 2021, after this paper: background citation

Comparison of Traditional High-Load Training With Low-Load Plus Blood Flow Restriction Training on Strength, Function, and Self-Reported Outcomes in Patients With Rheumatoid Disorders

TypeinterventionalSponsorLouisiana State University Health Sciences Center ShreveportRan2021 to 2023Enrolled4ConditionsRheumatoid Arthritis, Myositis, Osteoarthritis, Weakness, MuscleArmsStrength Training
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

A R SantosSchool of Physical Education and Sport, University of São Paulo, Brazil ; Both authors contributed equally to this paper.
M T NevesDivision of Rheumatology, School of Medicine, University of São Paulo, Brazil ; Both authors contributed equally to this paper.
B GualanoSchool of Physical Education and Sport, University of São Paulo, Brazil ; Division of Rheumatology, School of Medicine, University of São Paulo, Brazil.
G C LaurentinoSchool of Physical Education and Sport, University of São Paulo, Brazil.
A H LanchaSchool of Physical Education and Sport, University of São Paulo, Brazil.
C UgrinowitschSchool of Physical Education and Sport, University of São Paulo, Brazil.
F R LimaDivision of Rheumatology, School of Medicine, University of São Paulo, Brazil.
M S AokiSchool of Arts, Sciences, and Humanities, University of São Paulo, Brazil.
Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledInclusion body myositis is a rare idiopathic inflammatory myopathy that produces extreme muscle weakness. Blood flow restricted resistance training has been shown to improve muscle strength and muscle hypertrophy in inclusion body myositis.

objectiveThe aim of this study was to evaluate the effects of a resistance training programme on the expression of genes related to myostatin (MSTN) signalling in one inclusion body myositis patient.

methodsA 65-year-old man with inclusion body myositis underwent blood flow restricted resistance training for 12 weeks. The gene expression of MSTN, follistatin, follistatin-like 3, activin II B receptor, SMAD-7, MyoD, FOXO-3, and MURF-2 was quantified.

resultsAfter 12 weeks of training, a decrease (25%) in MSTN mRNA level was observed, whereas follistatin and follistatin-like 3 gene expression increased by 40% and 70%, respectively. SMAD-7 mRNA level was augmented (20%). FOXO-3 and MURF-2 gene expression increased by 40% and 20%, respectively. No change was observed in activin II B receptor or MyoD gene expression.

conclusionsBlood flow restricted resistance training attenuated MSTN gene expression and also increased expression of myostatin endogenous inhibitors. Blood flow restricted resistance training evoked changes in the expression of genes related to MSTN signalling pathway that could in part explain the muscle hypertrophy previously observed in a patient with inclusion body myositis.

Indexed as

GDF-8mRNAmuscle hypertrophyreal-time PCR

Identifiers

PMID24899776
PMCPMC4042658
OpenAlexW2136528269

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.