ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Response normalization in the superficial layers of the superior colliculus as a possible mechanism for saccadic averaging.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Distinct neural geometries for target position and velocity in the primate superior colliculus.bioRxiv : the preprint server for biology · 2026Article
- Alpha-Band Activity Tracks Reflexive Changes in the Breadth of the Zoom Lens of Attention.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Recurrent circuits encode de novo visual center-surround computations in the mouse superior colliculus.PLoS biology · 2025Article
- Probabilistically constrained vector summation of motion direction in the mouse superior colliculus.Current biology : CB · 2025Article
- Combined manifestation of two geometric visual illusions.Attention, perception & psychophysics · 2024Article
- Effects of normalized summation in the visual illusion of extent.Attention, perception & psychophysics · 2023Article
- Neural mechanisms for the localization of unexpected external motion.Nature communications · 2023Article
- A theory of autism bridging across levels of description.Trends in cognitive sciences · 2023Review
- A dynamic neural field model of continuous input integration.Biological cybernetics · 2021Article
- Quantitative examination of an unconventional form of the filled-space illusion.Attention, perception & psychophysics · 2021Article
- Inhibition of saccade initiation improves saccade accuracy: The role of local and remote visual distractors in the control of saccadic eye movements.Journal of vision · 2021Article
- Dissociable Cortical and Subcortical Mechanisms for Mediating the Influences of Visual Cues on Microsaccadic Eye Movements.Frontiers in neural circuits · 2021Review
- Visual attention is not deployed at the endpoint of averaging saccades.PLoS biology · 2018Article
- Normal Topography and Binocularity of the Superior Colliculus in Strabismus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Integrating Brain and Biomechanical Models-A New Paradigm for Understanding Neuro-muscular Control.Frontiers in neuroscience · 2018Article
- Circuits for Action and Cognition: A View from the Superior Colliculus.Annual review of vision science · 2017Review
- How is visual salience computed in the brain? Insights from behaviour, neurobiology and modelling.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- A Model of the Superior Colliculus Predicts Fixation Locations during Scene Viewing and Visual Search.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Normal correspondence of tectal maps for saccadic eye movements in strabismus.Journal of neurophysiology · 2016Article
- Suppressive interactions underlying visually evoked fixational saccades.Vision research · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
How does the brain decide where to look? Neuronal networks within the superior colliculus (SC) encode locations of intended eye movements. When faced with multiple targets, the relative activities of neuronal populations compete for the selection of a saccade. However, the computational principles underlying saccadic choices remain poorly understood. We used voltage imaging of slices of rat SC to record circuit dynamics of population responses to single- and dual-site electrical stimulation to begin to reveal some of the principles of how populations of neurons interact. Stimulation of two distant sites simultaneously within the SC produced two distinct peaks of activity, whereas stimulation of two nearby sites simultaneously exhibited a single, merged peak centered between the two sites. The distances required to produce merged peaks of activity corresponded to target separations that evoked averaging saccades in humans performing a corresponding dual target task. The merged activity was well accounted for by a linear weighed summation and a divisive normalization of the responses evoked by the single-site stimulations. Interestingly, the merging of activity occurred within the superficial SC, suggesting a novel pathway for saccadic eye movement choice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.