ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
BDNF signaling in the VTA links the drug-dependent state to drug withdrawal aversions.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 59 citations in OpenAlex.
- Genetic variation in BDNF is associated with opioid use disorder severity.Human genetics · 2026Article
- BDNF restores impaired long-term potentiation of GABAergic synapses induced by chronic ethanol exposure in the VTA and attenuates reward-seeking behavior.Molecular psychiatry · 2026Article
- The actions of morphine on microglia and the underlying effects on associated adverse effects.Psychopharmacology · 2026Review
- Aging reduces motivation through decreased Bdnf expression in the ventral tegmental area.Molecular psychiatry · 2026Article
- The role of lymphocytic CD5 in the effects of ethanol on mesolimbic circuitry and ethanol consumption behavior.Brain, behavior, and immunity · 2026Article
- Opioid-driven disruption of the septum reveals a role for neurotensin-expressing neurons in withdrawal.Neuron · 2025Article
- Catharanthine Modulates Mesolimbic Dopamine Transmission and Nicotine Psychomotor Effects via Inhibition of α6-Nicotinic Receptors and Dopamine Transporters.ACS chemical neuroscience · 2024Article
- Whole-Body Vibration Prevents Neuronal, Neurochemical, and Behavioral Effects of Morphine Withdrawal in a Rat Model.International journal of molecular sciences · 2023Article
- Role of α6-Nicotinic Receptors in Alcohol-Induced GABAergic Synaptic Transmission and Plasticity to Cholinergic Interneurons in the Nucleus Accumbens.Molecular neurobiology · 2023Article
- Hallucinogenic potential: a review of psychoplastogens for the treatment of opioid use disorder.Frontiers in pharmacology · 2023Review
- Opioid-induced microglia reactivity modulates opioid reward, analgesia, and behavior.Neuroscience and biobehavioral reviews · 2022Review
- Glutamatergic Systems and Memory Mechanisms Underlying Opioid Addiction.Cold Spring Harbor perspectives in medicine · 2021Review
- Opioid-Induced Molecular and Cellular Plasticity of Ventral Tegmental Area Dopamine Neurons.Cold Spring Harbor perspectives in medicine · 2021Review
- Protagonist Role of Opioidergic System on Post-Traumatic Stress Disorder and Associated Pain.Psychiatry investigation · 2020Article
- Overlap in the neural circuitry and molecular mechanisms underlying ketamine abuse and its use as an antidepressant.Behavioural brain research · 2020Review
- Co-administration of ethanol and nicotine heightens sensitivity to ethanol reward within the nucleus accumbens (NAc) shell and increasing NAc shell BDNF is sufficient to enhance ethanol reward in naïve Wistar rats.Journal of neurochemistry · 2020Article
- Pharmacological Antagonism of T-Type Calcium Channels Constrains Rebound Burst Firing in Two Distinct Subpopulations of GABA Neurons in the Rat Ventral Tegmental Area: Implications for α-Lipoic Acid.Frontiers in pharmacology · 2019Article
- Inhibitory Plasticity of Mesocorticolimbic Circuits in Addiction and Mental Illness.Trends in neurosciences · 2018Review
- Targeting histone deacetylation for recovery of maternal deprivation-induced changes in BDNF and AKAP150 expression in the VTA.Experimental neurology · 2018Article
- Acupuncture on the Stress-Related Drug Relapse to Seeking.Evidence-based complementary and alternative medicine : eCAM · 2018Review
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 4 countries.
Funding
Abstract
Drug administration to avoid unpleasant drug withdrawal symptoms has been hypothesized to be a crucial factor that leads to compulsive drug-taking behavior. However, the neural relationship between the aversive motivational state produced by drug withdrawal and the development of the drug-dependent state still remains elusive. It has been observed that chronic exposure to drugs of abuse increases brain-derived neurotrophic factor (BDNF) levels in ventral tegmental area (VTA) neurons. In particular, BDNF expression is dramatically increased during drug withdrawal, which would suggest a direct connection between the aversive state of withdrawal and BDNF-induced neuronal plasticity. Using lentivirus-mediated gene transfer to locally knock down the expression of the BDNF receptor tropomyosin-receptor-kinase type B in rats and mice, we observed that chronic opiate administration activates BDNF-related neuronal plasticity in the VTA that is necessary for both the establishment of an opiate-dependent state and aversive withdrawal motivation. Our findings highlight the importance of a bivalent, plastic mechanism that drives the negative reinforcement underlying addiction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.