Evidence map›Paper›PMID 24899709›Full record

Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2014

Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults.

A Veronica Witte, Lucia Kerti, Daniel S Margulies, Agnes Flöel

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 203 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
203citing papers in PubMed, 11 pooled it
24.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

203 citing papers in PubMed, 11 syntheses or guidelines pooled it, 439 citations in OpenAlex.

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  17. Effects of 90 Days of Resveratrol Supplementation on Cognitive Function in Elders: A Pilot Study.Journal of alternative and complementary medicine (New York, N.Y.) · 2018
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143 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

A Veronica WitteDepartment of Neurology, NeuroCure Cluster of Excellence, and veronica.witte@charite.de agnes.floeel@charite.de.
Lucia KertiDepartment of Neurology.
Daniel S MarguliesMax Planck Research Group: Neuroanatomy and Connectivity, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany.
Agnes FlöelDepartment of Neurology, NeuroCure Cluster of Excellence, and Center for Stroke Research Berlin, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany; and veronica.witte@charite.de agnes.floeel@charite.de.
CURE International UK · GBMax Planck Institute for Human Cognitive and Brain Sciences · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dietary habits such as caloric restriction or nutrients that mimic these effects may exert beneficial effects on brain aging. The plant-derived polyphenol resveratrol has been shown to increase memory performance in primates; however, interventional studies in older humans are lacking. Here, we tested whether supplementation of resveratrol would enhance memory performance in older adults and addressed potential mechanisms underlying this effect. Twenty-three healthy overweight older individuals that successfully completed 26 weeks of resveratrol intake (200 mg/d) were pairwise matched to 23 participants that received placebo (total n = 46, 18 females, 50-75 years). Before and after the intervention/control period, subjects underwent memory tasks and neuroimaging to assess volume, microstructure, and functional connectivity (FC) of the hippocampus, a key region implicated in memory functions. In addition, anthropometry, glucose and lipid metabolism, inflammation, neurotrophic factors, and vascular parameters were assayed. We observed a significant effect of resveratrol on retention of words over 30 min compared with placebo (p = 0.038). In addition, resveratrol led to significant increases in hippocampal FC, decreases in glycated hemoglobin (HbA1c) and body fat, and increases in leptin compared with placebo (all p < 0.05). Increases in FC between the left posterior hippocampus and the medial prefrontal cortex correlated with increases in retention scores and with decreases in HbA1c (all p < 0.05). This study provides initial evidence that supplementary resveratrol improves memory performance in association with improved glucose metabolism and increased hippocampal FC in older adults. Our findings offer the basis for novel strategies to maintain brain health during aging.

Indexed as

AgedAged, 80 and overAntioxidantsBlood GlucoseCase-Control StudiesCognitionFastingFemaleFollow-Up StudiesGlycated HemoglobinHippocampusHumansLeptinMaleMemoryMiddle AgedAntioxidantsBlood GlucoseGlycated HemoglobinLeptinQuercetinResveratrolStilbenesAgingCR-mimeticHbA1cmicrostructureresting-state fMRI

Identifiers

PMID24899709
PMCPMC6608268
OpenAlexW2160427616

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.