ArticleJournal of neurophysiology2014
Disrupting information coding via block of 4-AP-sensitive potassium channels.
Article in Journal of neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Adult-neurogenesis allows for representational stability and flexibility in early olfactory system.eLife · 2026Article
- A biophysical and statistical modeling paradigm for connecting neural physiology and function.Journal of computational neuroscience · 2023Article
- Full-bandwidth electrophysiology of seizures and epileptiform activity enabled by flexible graphene microtransistor depth neural probes.Nature nanotechnology · 2022Article
- Excitable Axonal Domains Adapt to Sensory Deprivation in the Olfactory System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Voltage-Gated Ion Channels and the Variability in Information Transfer.Frontiers in cellular neuroscience · 2022Article
- Compensatory variability in network parameters enhances memory performance in theProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Cell and circuit origins of fast network oscillations in the mammalian main olfactory bulb.eLife · 2021Article
- Changes in pairwise correlations during running reshape global network state in the main olfactory bulb.Journal of neurophysiology · 2021Article
- Ion-channel regulation of response decorrelation in a heterogeneous multi-scale model of the dentate gyrus.Current research in neurobiology · 2021Article
- Disparate forms of heterogeneities and interactions among them drive channel decorrelation in the dentate gyrus: Degeneracy and dominance.Hippocampus · 2019Article
- Diverse Representations of Olfactory Information in Centrifugal Feedback Projections.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- The incretin hormone glucagon-like peptide 1 increases mitral cell excitability by decreasing conductance of a voltage-dependent potassium channel.The Journal of physiology · 2016Article
- Computational implications of biophysical diversity and multiple timescales in neurons and synapses for circuit performance.Current opinion in neurobiology · 2016Review
- Mitochondrial Ultrastructure and Glucose Signaling Pathways Attributed to the Kv1.3 Ion Channel.Frontiers in physiology · 2016Article
- Postnatal development attunes olfactory bulb mitral cells to high-frequency signaling.Journal of neurophysiology · 2015Article
- An Empirical Model for Reliable Spiking Activity.Neural computation · 2015Article
- Diverse cortical codes for scene segmentation in primate auditory cortex.Journal of neurophysiology · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Recent interest has emerged on the role of intrinsic biophysical diversity in neuronal coding. An important question in neurophysiology is understanding which voltage-gated ion channels are responsible for this diversity and how variable expression or activity of one class of ion channels across neurons of a single type affects they way populations carry information. In mitral cells in the olfactory bulb of mice, we found that biophysical diversity was conferred in part by 4-aminopyridine (4-AP)-sensitive potassium channels and reduced following block of those channels. When populations of mitral cells were stimulated with identical inputs, the diversity exhibited in their output spike patterns reduced with the addition of 4-AP, decreasing the stimulus information carried by ensembles of 15 neurons from 437 ± 15 to 397 ± 19 bits/s. Decreases in information were due to reduction in the diversity of population spike patterns generated in response to different features of the stimulus, suggesting that the coding capacity of a population can be altered by changes in the function of single ion channel types.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.