Evidence map›Paper›PMID 24899576›Full record

ReviewBiology of reproduction2014

Engineered nanomaterials: an emerging class of novel endocrine disruptors.

Jeremy K Larson, Michael J Carvan, Reinhold J Hutz

Abstract readReview
In one paragraph

Review in Biology of reproduction, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Therapeutic nanoparticle safety in pregnancy: Bridging knowledge gaps with environmental insights and a translational roadmap.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Maternal Engineered Nanomaterial Inhalation During Gestation Disrupts Vascular Kisspeptin Reactivity.Toxicological sciences : an official journal of the Society of Toxicology · 2019
    Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jeremy K LarsonDepartment of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin Children's Environmental Health Sciences Core Center at the University of Wisconsin-Milwaukee and Children's Research Institute, Milwaukee, Wisconsin.
Michael J CarvanDepartment of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin Children's Environmental Health Sciences Core Center at the University of Wisconsin-Milwaukee and Children's Research Institute, Milwaukee, Wisconsin School of Freshwater Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
Reinhold J HutzDepartment of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin Children's Environmental Health Sciences Core Center at the University of Wisconsin-Milwaukee and Children's Research Institute, Milwaukee, Wisconsin School of Freshwater Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin rjhutz@uwm.edu.

Funding

Pilot Project ProgramP30ES004184 · NIEHS · UNIVERSITY OF WISCONSIN MILWAUKEE · PI PETERING, DAVID HAROLD · 1987 to 2015
$11.8M
NIEHS NIH HHS P30 ES004184
6 · The paper itself

Abstract

Over the past decade, engineered nanomaterials (ENMs) have garnered great attention for their potentially beneficial applications in medicine, industry, and consumer products due to their advantageous physicochemical properties and inherent size. However, studies have shown that these sophisticated molecules can initiate toxicity at the subcellular, cellular, and/or tissue/organ level in diverse experimental models. Investigators have also demonstrated that, upon exposure to ENMs, the physicochemical properties that are exploited for public benefit may mediate adverse endocrine-disrupting effects on several endpoints of mammalian reproductive physiology (e.g., steroidogenesis, spermatogenesis, pregnancy). Elucidating these complex interactions within reproductive cells and tissues will significantly advance our understanding of ENMs as an emerging class of novel endocrine disruptors and reproductive toxicants. Herein we reviewed the recent developments in reproductive nanotoxicology and identified the gaps in our knowledge that may serve as future research directions to foster continued advancement in this evolving field of study.

Indexed as

AnimalsEndocrine DisruptorsFemaleFertilityHumansMaleNanostructuresReproductionEndocrine Disruptorsendocrine disruptorsengineered nanomaterialsnanotoxicologyreproductionsteroidogenesis

Identifiers

PMID24899576
PMCPMC4434961

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.