Evidence map›Paper›PMID 24899518›Full record

ArticleAngewandte Chemie (International ed. in English)2014

Complex reconfiguration of DNA nanostructures.

Bryan Wei, Luvena L Ong, Jeffrey Chen, Alexander S Jaffe, Peng Yin

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Building machines with DNA molecules.Nature reviews. Genetics · 2020
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. DNA nanostructures: a shift from assembly to applications.Current opinion in chemical engineering · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bryan WeiWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115 (USA) http://molecular-systems.net http://yin.hms.harvard.edu; Department of Systems Biology, Harvard Medical School, Boston, MA 02115 (USA). bryan.wei@wyss.harvard.edu.
Luvena L Ong
Jeffrey Chen
Alexander S Jaffe
Peng Yin

Funding

Engineering Bioimaging Probes Based on Triggered Molecular GeometryDP2OD007292 · OD · HARVARD MEDICAL SCHOOL · PI YIN, PENG · 2010 to 2010
$2.5M
NIH HHS 1DP2OD007292NIH HHS DP2 OD007292
6 · The paper itself

Abstract

Nucleic acids have been used to create diverse synthetic structural and dynamic systems. Toehold-mediated strand displacement has enabled the construction of sophisticated circuits, motors, and molecular computers. Yet it remains challenging to demonstrate complex structural reconfiguration in which a structure changes from a starting shape to another arbitrarily prescribed shape. To address this challenge, we have developed a general structural-reconfiguration method that utilizes the modularly interconnected architecture of single-stranded DNA tile and brick structures. The removal of one component strand reveals a newly exposed toehold on a neighboring strand, thus enabling us to remove regions of connected component strands without the need to modify the strands with predesigned external toeholds. By using this method, we reconfigured a two-dimensional rectangular DNA canvas into diverse prescribed shapes. We also used this method to reconfigure a three-dimensional DNA cuboid.

Indexed as

NanostructuresNucleic Acid ConformationDNAMicroscopy, Atomic ForceDNADNA bricksnanostructuressingle-stranded tilesstrand displacementstructural reconfiguration

Identifiers

PMID24899518
PMCPMC4235524

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.