Evidence map›Paper›PMID 24899469›Full record

ReviewReproductive sciences (Thousand Oaks, Calif.)2014

Influenza, immune system, and pregnancy.

Renju S Raj, Elizabeth A Bonney, Mark Phillippe

Open access · bronzeAbstract readReview
In one paragraph

Review in Reproductive sciences (Thousand Oaks, Calif.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 89 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Immune Response to Respiratory Viral Infections.International journal of molecular sciences · 2024
    Review
  11. Maternal Influenza and Offspring Neurodevelopment.Current issues in molecular biology · 2024
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Pregnancy and pandemics: Interaction of viral surface proteins and placenta cells.Biochimica et biophysica acta. Molecular basis of disease · 2021
    Review
  20. A literature review on beneficial role of vitamins and trace elements: Evidence from published clinical studies.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Renju S RajDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont College of Medicine, Burlington, VT, USA.
Elizabeth A BonneyDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont College of Medicine, Burlington, VT, USA.
Mark PhillippeDepartment of Obstetrics & Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA mphillippe@mgh.harvard.edu.
University of Vermont · USMassachusetts General Hospital · US

Funding

VERMONT IMMUNOBIOLOIGY/ INFECTIOUS DISEASES CENTERP20RR021905 · NCRR · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI DIENZ, OLIVER · 2006 to 2011
$14.5M
Vermont Immunobioloigy/ Infectious Diseases CenterP20GM103496 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BUDD, RALPH C · 2012 to 2015
$8.7M
WRHR - A Mentoring Program in Women's Reproductive Health Research at the UniversK12HD063082 · NICHD · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BERNSTEIN, IRA MARK · 2009 to 2013
$2.1M
Severe H1N1 Influenza Infection During Pregnancy: Pathophysiologic MechanismsR21HD065396 · NICHD · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI PHILLIPPE, MARK · 2010 to 2010
$228k
NCRR NIH HHS P20 RR021905NICHD NIH HHS 12HD063082NICHD NIH HHS K12 HD063082NICHD NIH HHS R21 HD065396NIGMS NIH HHS P20 GM103496
6 · The paper itself

Abstract

Influenza is a major health problem worldwide. Both seasonal influenza and pandemics take a major toll on the health and economy of our country. The present review focuses on the virology and complex immunology of this RNA virus in general and in relation to pregnancy. The goal is to attempt to explain the increased morbidity and mortality seen in infection during pregnancy. We discuss elements of innate and adaptive immunity as well as placental cellular responses to infection. In addition, we delineate findings in animal models as well as human disease. Increased knowledge of maternal and fetal immunologic responses to influenza is needed. However, enhanced understanding of nonimmune, pregnancy-specific factors influencing direct interaction of the virus with host cells is also important for the development of more effective prevention and treatment options in the future.

Indexed as

Adaptive ImmunityAnimalsDisease Models, AnimalFemaleHost-Pathogen InteractionsHumansImmune SystemImmunity, InnateImmunizationInfluenza, HumanInfluenza VaccinesOrthomyxoviridaePregnancyPregnancy Complications, InfectiousPrognosisRisk FactorsInfluenza Vaccinesadaptive immunityinfluenzainnate immunitypregnancy

Identifiers

PMID24899469
PMCPMC4231130
OpenAlexW2142392174

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.