Observational studyReproductive sciences (Thousand Oaks, Calif.)2015
2-methoxyestradiol plasma levels are associated with clinical severity indices and biomarkers of preeclampsia.
Observational study in Reproductive sciences (Thousand Oaks, Calif.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Uric Acid and Preeclampsia: Pathophysiological Interactions and the Emerging Role of Inflammasome Activation.Antioxidants (Basel, Switzerland) · 2025Review
- Click estradiol dimers with novel aromatic bridging units: synthesis and anticancer evaluation.Journal of enzyme inhibition and medicinal chemistry · 2024Article
- Pregnancy by Oocyte Donation: Reviewing Fetal-Maternal Risks and Complications.International journal of molecular sciences · 2023Review
- Sex differences in placenta-derived markers and later autistic traits in children.Translational psychiatry · 2023Article
- Factors Involved in Endothelial Dysfunction Related to Angiogenic Disbalance and Oxidative Stress, in Women at High Risk of Term Pre-Eclampsia.Antioxidants (Basel, Switzerland) · 2022Article
- Secretory products of the corpus luteum and preeclampsia.Human reproduction update · 2021Review
- Estrogen and Preeclampsia: Potential of Estrogens as Therapeutic Agents in Preeclampsia.Drug design, development and therapy · 2021Review
- Association of 2-Methoxyestradiol (2ME) Plasma Levels with Clinical Severity Indices and Biomarkers of Preeclampsia.Journal of obstetrics and gynaecology of India · 2019Article
- Loss of placental growth factor ameliorates maternal hypertension and preeclampsia in mice.The Journal of clinical investigation · 2018Article
- Lipidomics in translational research and the clinical significance of lipid-based biomarkers.Translational research : the journal of laboratory and clinical medicine · 2017Review
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Authors and funding
9 authors.
Funding
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Abstract
We investigated whether clinical severity indices and biomarkers for preeclampsia (PE) are associated with low plasmatic 2-methoxyestradiol (2ME) in the third trimester of gestation. Blood was collected from 53 women with PE and 73 control pregnant women before parturition. The concentration of 2ME was significantly higher in controls than in patients with PE (2906.43 ± 200.69 pg/mL vs 1818.41 ± 189.25 pg/mL). The risk of PE decreased as 2ME levels increased. The 2ME values were negatively correlated with systolic peak arterial pressure and proteinuria in PE. Additionally, those women with PE with lower 2ME had a more serious clinical situation and needed a more aggressive therapy. Finally, 2ME levels (in patients with PE and total population) were significantly correlated with concentrations of soluble fms-like tyrosine kinase 1 and placental growth factor . Summarizing, patients with PE had lower 2ME levels that were correlated with different clinical indices and biomarkers of severity, indicating that 2ME could be taken into account for the clinical management of this syndrome.
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