ArticleJournal of Asian natural products research2014
Alkaloids from the hook-bearing branch of Uncariarhynchophylla and their neuroprotective effects against glutamate-induced HT22 cell death.
Article in Journal of Asian natural products research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- New Monoterpenoid Indole Alkaloids as Potential Neuroprotective Agents fromMolecules (Basel, Switzerland) · 2026Article
- Decoding natural products for neuroprotection: Pathway networks and structural insights for drug development.Chinese herbal medicines · 2025Review
- Article
- Growth Inhibitory and Pro-Apoptotic Effects of Hirsuteine in Chronic Myeloid Leukemia Cells through Targeting Sphingosine Kinase 1.Biomolecules & therapeutics · 2022Article
- Protection against HTranslational neuroscience · 2022Article
- Natural Products for the Prevention and Control of the COVID-19 Pandemic: Sustainable Bioresources.Frontiers in pharmacology · 2021Review
- Antihypernociceptive and Neuroprotective Effects of the Aqueous and Methanol Stem-Bark Extracts ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Properties, Pharmacology, and Pharmacokinetics of Active Indole and Oxindole Alkaloids inFrontiers in pharmacology · 2021Review
- Antiepileptic geissoschizine methyl ether is an inhibitor of multiple neuronal channels.Acta pharmacologica Sinica · 2020Article
- Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla.Natural products and bioprospecting · 2017Article
- Geissoschizine methyl ether protects oxidative stress-mediated cytotoxicity in neurons through the 'Neuronal Warburg Effect'.Journal of ethnopharmacology · 2016Article
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Authors and funding
6 authors.
Funding
Abstract
One new alkaloid, 4-geissoschizine N-oxide methyl ether (1), was isolated from the EtOH extract of the hook-bearing branch of Uncariarhynchophylla, together with 10 known alkaloids, 3-epi-geissoschizine methyl ether (2) isolated from U.rhynchophylla for the first time, geissoschizine methyl ether (3), 4-hirsuteine N-oxide (4), hirsuteine (5), hirsutine (6), 3α-dihydro-cadambine (7), 3β-isodihydro-cadambine (8), cadambine (9), strictosamide (10), and akuammigine (11). The structures were elucidated by spectroscopic methods including UV, ESI-QTOF MS, NMR, and circular dichroism experiments. Neuroprotective effects of 1-9 were investigated against 3 mM glutamate-induced HT22 cell death. The activity assay showed that 2, 3, 5, and 6 exhibited potent neuroprotective effects against glutamate-induced HT22 cell death. However, only weak neuroprotective activities were observed for 1, 4, 7, 8, and 9.
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