ArticleJournal of virology2014
Identification of B cells as a major site for cyprinid herpesvirus 3 latency.
Article in Journal of virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 60 citations in OpenAlex.
- Investigation of β-Carboline Alkaloid Harmaline AgainstViruses · 2025Article
- Peripheral B Lymphocyte Serves as a Reservoir for the Persistently Covert Infection of Mandarin FishViruses · 2024Article
- A review of latency in the Alloherpesviridae family.Journal of fish diseases · 2024Review
- Transcriptomic Responses to Koi Herpesvirus in Isolated Blood Leukocytes from Infected Common Carp.Viruses · 2024Article
- Acipenserid herpesvirus 2 genome and partial validation of a qPCR for its detection in white sturgeon Acipenser transmontanus.Diseases of aquatic organisms · 2024Article
- The Resistance to Lethal Challenge withViruses · 2023Article
- A Seasonal Study of Koi Herpesvirus and Koi Sleepy Disease Outbreaks in the United Kingdom in 2018 Using a Pond-Side Test.Animals : an open access journal from MDPI · 2021Article
- Seroconversion and Skin Mucosal Parameters during Koi Herpesvirus Shedding in Common Carp,International journal of molecular sciences · 2020Article
- Article
- Evaluation of Cyprinid Herpesvirus 2 Latency and Reactivation inMicroorganisms · 2020Article
- Pharmacokinetic and Efficacy Study of Acyclovir Against Cyprinid Herpesvirus 3 inFrontiers in veterinary science · 2020Article
- Article
- Cyprinid Herpesvirus 2 miR-C12 Attenuates Virus-Mediated Apoptosis and Promotes Virus Propagation by TargetingFrontiers in microbiology · 2019Article
- Detection of koi herpesvirus in healthy common carps,Virusdisease · 2018Article
- Genomic and biologic comparisons of cyprinid herpesvirus 3 strains.Veterinary research · 2018Article
- Conserved Fever Pathways across Vertebrates: A Herpesvirus Expressed Decoy TNF-α Receptor Delays Behavioral Fever in Fish.Cell host & microbe · 2017Article
- Cyprinid herpesvirus 3 and its evolutionary future as a biological control agent for carp in Australia.Virology journal · 2016Article
- Rapid Detection of Cyprinid Herpesvirus 3 in Latently Infected Koi by Recombinase Polymerase Amplification.Journal of aquatic animal health · 2016Article
- Mutations in the C-terminal region affect subcellular localization of crucian carp herpesvirus (CaHV) GPCR.Virus genes · 2016Article
- Application of a nanoflare probe specific to a latency associated transcript for isolation of KHV latently infected cells.Virus research · 2015Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
unlabelledCyprinid herpesvirus 3 (CyHV-3), commonly known as koi herpesvirus (KHV), is a member of the Alloherpesviridae, and is a recently discovered emerging herpesvirus that is highly pathogenic for koi and common carp. Our previous study demonstrated that CyHV-3 becomes latent in peripheral white blood cells (WBC). In this study, CyHV-3 latency was further investigated in IgM(+) WBC. The presence of the CyHV-3 genome in IgM(+) WBC was about 20-fold greater than in IgM(-) WBC. To determine whether CyHV-3 expressed genes during latency, transcription from all eight open reading frames (ORFs) in the terminal repeat was investigated in IgM(+) WBC from koi with latent CyHV-3 infection. Only a spliced ORF6 transcript was found to be abundantly expressed in IgM(+) WBC from CyHV-3 latently infected koi. The spliced ORF6 transcript was also detected in vitro during productive infection as early as 1 day postinfection. The ORF6 transcript from in vitro infection begins at -127 bp upstream of the ATG codon and ends +188 bp downstream of the stop codon, +20 bp downstream of the polyadenylation signal. The hypothetical protein of ORF6 contains a consensus sequence with homology to a conserved domain of EBNA-3B and ICP4 from Epstein-Barr virus and herpes simplex virus 1, respectively, both members of the Herpesviridae. This is the first report of latent CyHV-3 in B cells and identification of gene transcription during latency for a member of the Alloherpesviridae. IMPORTANCE: This is the first demonstration that a member of the Alloherpesviridae, cyprinid herpesvirus 3 (CyHV-3), establishes a latent infection in the B cells of its host, Cyprinus carpio. In addition, this is the first report of identification of gene transcription during latency for a member of Herpesvirales outside Herpesviridae. This is also the first report that the hypothetical protein of latent transcript of CyHV-3 contains a consensus sequence with homology to a conserved domain of EBNA-3B from Epstein-Barr virus and ICP4 from herpes simplex virus 1, which are genes important for latency. These strongly suggest that latency is evolutionally conserved across vertebrates.
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