ArticleAmerican journal of physiology. Renal physiology2014
Impact of renal medullary three-dimensional architecture on oxygen transport.
Article in American journal of physiology. Renal physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 65 citations in OpenAlex.
- Vigorous physical activity as a potential environmental risk factor in renal medullary carcinoma.Urologic oncology · 2025Article
- AI-Driven Prediction of Renal Stone Recurrence Following ECIRS: A Machine Learning Approach to Postoperative Risk Stratification Incorporating 24-Hour Urine Data.Journal of clinical medicine · 2025Article
- Anemia and Hypoxia Impact on Chronic Kidney Disease Onset and Progression: Review and Updates.Cureus · 2023Review
- Comprehensive Management of Blood Pressure in Patients with Septic AKI.Journal of clinical medicine · 2023Review
- Renal blood flow and oxygenation.Pflugers Archiv : European journal of physiology · 2022Review
- Sex-Specific Computational Models of Kidney Function in Patients With Diabetes.Frontiers in physiology · 2022Article
- Reply to Bankir: the ever-expanding role of lactate in the kidney.American journal of physiology. Renal physiology · 2021Article
- Sex differences in solute and water handling in the human kidney: Modeling and functional implications.iScience · 2021Article
- Sex differences in solute transport along the nephrons: effects of NaAmerican journal of physiology. Renal physiology · 2020Article
- A model of mitochondrial OAmerican journal of physiology. Renal physiology · 2020Article
- A Computer Model of Oxygen Dynamics in the Cortex of the Rat Kidney at the Cell-Tissue Level.International journal of molecular sciences · 2019Article
- Functional implications of the sex differences in transporter abundance along the rat nephron: modeling and analysis.American journal of physiology. Renal physiology · 2019Article
- Solute and water transport along an inner medullary collecting duct undergoing peristaltic contractions.American journal of physiology. Renal physiology · 2019Article
- Understanding sex differences in long-term blood pressure regulation: insights from experimental studies and computational modeling.American journal of physiology. Heart and circulatory physiology · 2019Article
- Recent advances in sex differences in kidney function.American journal of physiology. Renal physiology · 2019Article
- Mammalian urine concentration: a review of renal medullary architecture and membrane transporters.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2018Review
- Nitric Oxide Synthase Inhibition Induces Renal Medullary Hypoxia in Conscious Rats.Journal of the American Heart Association · 2018Article
- Renal medullary and urinary oxygen tension during cardiopulmonary bypass in the rat.Mathematical medicine and biology : a journal of the IMA · 2017Article
- Sex-specific computational models of the spontaneously hypertensive rat kidneys: factors affecting nitric oxide bioavailability.American journal of physiology. Renal physiology · 2017Article
- Coping with nephron loss: transport at a price.American journal of physiology. Renal physiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
We have developed a highly detailed mathematical model of solute transport in the renal medulla of the rat kidney to study the impact of the structured organization of nephrons and vessels revealed in anatomic studies. The model represents the arrangement of tubules around a vascular bundle in the outer medulla and around a collecting duct cluster in the upper inner medulla. Model simulations yield marked gradients in intrabundle and interbundle interstitial fluid oxygen tension (PO2), NaCl concentration, and osmolality in the outer medulla, owing to the vigorous active reabsorption of NaCl by the thick ascending limbs. In the inner medulla, where the thin ascending limbs do not mediate significant active NaCl transport, interstitial fluid composition becomes much more homogeneous with respect to NaCl, urea, and osmolality. Nonetheless, a substantial PO2 gradient remains, owing to the relatively high oxygen demand of the inner medullary collecting ducts. Perhaps more importantly, the model predicts that in the absence of the three-dimensional medullary architecture, oxygen delivery to the inner medulla would drastically decrease, with the terminal inner medulla nearly completely deprived of oxygen. Thus model results suggest that the functional role of the three-dimensional medullary architecture may be to preserve oxygen delivery to the papilla. Additionally, a simulation that represents low medullary blood flow suggests that the separation of thick limbs from the vascular bundles substantially increases the risk of the segments to hypoxic injury. When nephrons and vessels are more homogeneously distributed, luminal PO2 in the thick ascending limb of superficial nephrons increases by 66% in the inner stripe. Furthermore, simulations predict that owing to the Bohr effect, the presumed greater acidity of blood in the interbundle regions, where thick ascending limbs are located, relative to that in the vascular bundles, facilitates the delivery of O2 to support the high metabolic requirements of the thick limbs and raises NaCl reabsorption.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.