ArticleJournal of Alzheimer's disease : JAD2014
Positive association between plasma amylin and cognition in a homebound elderly population.
Article in Journal of Alzheimer's disease : JAD, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Non-fibril form but not fibril form of human islet amyloid polypeptide 8-20 changes brain functions in mice.PloS one · 2024Article
- Amylin Pharmacology in Alzheimer's Disease Pathogenesis and Treatment.Current neuropharmacology · 2022Review
- The Importance of Understanding Amylin Signaling Mechanisms for Therapeutic Development in the Treatment of Alzheimer's Disease.Current pharmaceutical design · 2020Review
- Activation of amylin receptors attenuates alcohol-mediated behaviours in rodents.Addiction biology · 2019Article
- Levels of islet amyloid polypeptide in cerebrospinal fluid and plasma from patients with Alzheimer's disease.PloS one · 2019Article
- Amylin in Alzheimer's disease: Pathological peptide or potential treatment?Neuropharmacology · 2018Review
- Improvement of spatial learning and memory, cortical gyrification patterns and brain oxidative stress markers in diabetic rats treated withJournal of traditional and complementary medicine · 2018Article
- Neuroprotective Effects of Amylin Analogues on Alzheimer's Disease Pathogenesis and Cognition.Journal of Alzheimer's disease : JAD · 2018Review
- Metabolism and Memory: Obesity, Diabetes, and Dementia.Biological psychiatry · 2017Article
- Amylin receptor ligands reduce the pathological cascade of Alzheimer's disease.Neuropharmacology · 2017Article
- Genome-wide interaction study of brain beta-amyloid burden and cognitive impairment in Alzheimer's disease.Molecular psychiatry · 2017Article
- Amylin-mediated control of glycemia, energy balance, and cognition.Physiology & behavior · 2016Review
- Unraveling Alzheimer's: Making Sense of the Relationship between Diabetes and Alzheimer's Disease1.Journal of Alzheimer's disease : JAD · 2016Review
- Plasma Amylin and Cognition in Diabetes in the Absence and the Presence of Insulin Treatment.Journal of diabetes & metabolism · 2014Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Our recent study reported that amylin, a pancreatic peptide that readily crosses the blood-brain barrier, improves learning and memory in Alzheimer's disease mouse models. However, the relationship between peripheral amylin and cognition in humans is unknown. In this follow-up study, using a cross-sectional, homebound elderly population, improvement in cognitive function with increasing quartiles of plasma amylin was suggested by positive association with verbal memory (p = 0.0002) and visuoconstruction tasks (p = 0.004), and inverse association with timed measures of attention (p < 0.0001) and executive function (p = 0.04). After adjusting for demographic information, apolipoprotein E4 allele, diabetes, stroke, kidney function, and lipid profile, log10 of plasma amylin remained associated with these cognitive domains. In contrast, plasma amyloid-β peptide was not associated with these specific cognitive domains. Our study suggests that peripheral amylin may be protective for cognitive decline, especially in the domains affected by Alzheimer's disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.