ReviewItalian journal of pediatrics2014
Looking for new treatments of Infantile Colic.
Review in Italian journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Manual Therapy Through Osteopathy in the Treatment of Infant Colic.
The Effect of Foot Reflexology on Infantile Colic Symptoms: Randomized, Placebo-Controlled Trial
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- The Relationship between Infant Colic and Migraine as well as Tension-Type Headache: A Meta-Analysis.Pain research & management · 2019Pooled it
- Acupuncture treatments for infantile colic: a systematic review and individual patient data meta-analysis of blinding test validated randomised controlled trials.Scandinavian journal of primary health care · 2018Pooled it
- Pooled it
- Osteopathic treatment of infants with infantile colic/excessive crying: a prospective, multicentric, randomized controlled trial and nested observational trial.BMC pediatrics · 2025Trial
- Effects of probiotics on gastrointestinal symptoms, anthropometric measurements, and breastfeeding duration in infants with colic: a randomized control trial.Sao Paulo medical journal = Revista paulista de medicina · 2024Trial
- The effect of behavioral therapy based counseling with anxious mothers on their infants' colic: a randomized controlled clinical trial.BMC pediatrics · 2022Trial
- Trial
- Simethicone Medication Should Be Avoided in Infants Receiving Oral Lactase Treatment.Children (Basel, Switzerland) · 2024Article
- Probiotics in Functional Gastrointestinal Disorders.Advances in experimental medicine and biology · 2024Review
- Probiotics added to maternal nutrition affect ınfantile colic symptoms and fecal microbiota profile: a single-blind randomized controlled study.Clinical and experimental pediatrics · 2022Article
- Efficacy of Aromatherapy for Night Crying in Infants with Infantile Colic: A Double-Blind Randomized Controlled Trial.International journal of preventive medicine · 2022Article
- Probiotics and Functional Gastrointestinal Disorders in Pediatric Age: A Narrative Review.Frontiers in pediatrics · 2022Review
- How Do Mothers Take Care of Their Infants with Colic Pain? A Mixed-Method Study.Ethiopian journal of health sciences · 2021Article
- Complementary and alternative medicine experiences of mothers in the treatment of infantile colic.Sudanese journal of paediatrics · 2020Article
- Perceived effectiveness of complementary medicine by mothers of infants with colic in Gauteng.Health SA = SA Gesondheid · 2019Article
- Infantile Colic: New Insights into an Old Problem.Gastroenterology clinics of North America · 2018Review
- Probiotics for management of infantile colic: a systematic review of randomized controlled trials.Archives of medical science : AMS · 2018Review
- Acupuncture for Infantile Colic: A Systematic Review of Randomised Controlled Trials.Evidence-based complementary and alternative medicine : eCAM · 2018Review
- Knowledge, attitudes, and practices of pediatricians on infantile colic in the Middle East and North Africa region.BMC pediatrics · 2017Article
- Pain-relieving agents for infantile colic.The Cochrane database of systematic reviews · 2016Review
Corrections and comments
- Commented on by
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infantile colic is a common disturbance occurring in the first three months of life. It is a benign condition and one of the main causes of pediatric consultation in the early part of life because of its great impact on family life. Some pediatricians are prone to undervalue this issue mainly because of the lack of evidence based medicine guidelines. Up to now, there is no consensus concerning management and treatment. Literature reports growing evidence about the effectiveness of dietary, pharmacological, complementary and behavioral therapies as options for the management of infantile colic. Dietary approach, usually based on the avoidance of cow's milk proteins in breast-feeding mothers and bottle-fed infants, more recently has seen the rise of new special formulas, such as partially hydrolyzed proteins and low lactose added with prebiotics or probiotics: their efficacy needs to be further documented. Investigated pharmacological agents are Simethicone and Cimetropium Bromide: the first is able to reduce bloating while the second could reduce fussing crying, but it has been tested only for severe infantile colic. No other pain relieving agents have been proposed until now, but some clinical trials are ongoing for new drugs.There is limited evidence supporting the use of complementary and alternative treatments (herbal supplements, manipulative approach and acupuncture) or behavioral interventions.Recent studies have focused the role of microbiota in the pathogenesis of this disturb and so new treatments, such as probiotics, have been proposed, but only few strains have been tested.Further investigations are needed in order to provide evidence-based guidelines.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.