Trial reportWorld journal of surgical oncology2014
Centrifugation versus PureGraft for fatgrafting to the breast after breast-conserving therapy.
Trial report in World journal of surgical oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Three-dimensional Quantitative Standards for Assessing Outcomes of Facial Lipotransfer: A Review.Aesthetic plastic surgery · 2023Pooled it
- Assessment of the Causes of Differences in Centrifugation Protocols as a Fat-Processing Technique: A Systematic Literature Review.Aesthetic plastic surgery · 2021Pooled it
- Meta-analysis of the oncological safety of autologous fat transfer after breast cancer.The British journal of surgery · 2018Pooled it
- Comparative Analysis of a New Automatic System and Four Existing Techniques for Autologous Fat Grafting.Plastic and reconstructive surgery. Global open · 2023Article
- Strategies to Improve AFT Volume Retention After Fat Grafting.Aesthetic plastic surgery · 2023Article
- Evolution of the Push-2-Spin Fat Graft Processing Device: Enhancing Efficiency and Reducing Risk of Contamination.Aesthetic surgery journal. Open forum · 2023Article
- Autologous Adipose-Derived Tissue Stromal Vascular Fraction (AD-tSVF) for Knee Osteoarthritis.International journal of molecular sciences · 2022Review
- The composition of cell-based therapies obtained from point-of-care devices/systems which mechanically dissociate lipoaspirate: a scoping review of the literature.Journal of experimental orthopaedics · 2022Article
- Adipose-Derived Stem Cells for Facial Rejuvenation.Journal of personalized medicine · 2022Review
- International Expert Panel Consensus on Fat Grafting of the Breast.Plastic and reconstructive surgery. Global open · 2019Article
- Novel dual-reporter transgenic rodents enable cell tracking in animal models of stem cell transplantation.Biochemistry and biophysics reports · 2019Article
- European Survey Study Among Plastic/Breast Surgeons on the Use of and Opinion Toward Autologous Fat Transfer: With Emphasis on Breast Surgery.Surgical innovation · 2018Article
- Mesenchymal Stem Cells from Adipose Tissue in Clinical Applications for Dermatological Indications and Skin Aging.International journal of molecular sciences · 2017Review
- Evaluation of Three Devices for the Isolation of the Stromal Vascular Fraction from Adipose Tissue and for ASC Culture: A Comparative Study.Stem cells international · 2017Article
- Autologous fat transplantation for breast reconstruction: A literature review.Annals of medicine and surgery (2012) · 2016Review
- Autologous fat transfer to the subcutaneous tissue in the context of breast reconstructive procedures.Postepy dermatologii i alergologii · 2016Review
- The BREAST-Q in surgical research: A review of the literature 2009-2015.Journal of plastic, reconstructive & aesthetic surgery : JPRAS · 2016Review
- Adipose Tissue and Mesenchymal Stem Cells: State of the Art and Lipogems® Technology Development.Current stem cell reportsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBreast-conserving treatment (BCT) leads to a progressive and deteriorating breast deformity. Fatgrafting is ideal for breast reconstruction after BCT. The most frequently utilized technique for fat processing is centrifugation. The PureGraft device (Cytori Therapeutics, San Diego, CA, USA) is a new method that involves washing and filtering the fat to prepare the graft. We compared the subjective and objective outcomes of two fat-processing methods, centrifugation and PureGraft filtration.
methodsThirty patients underwent breast reconstruction performed by a single surgeon (OM) after BCT in our department between April 2011 and September 2012. The patients were preoperatively divided into two groups randomly: 15 received fatgrafts processed by centrifugation, and 15 received fatgrafts processed by washing in PureGraft bags. The patients were followed up for 12 to 30 months. To measure the subjective outcome, we distributed the BREAST-Q questionnaire to all the patients both preoperatively and 1 year postoperatively. The BCCT.core software evaluated the objective outcome of breast reconstruction by fatgrafting.
resultsThe Breast-Q results indicated a tremendous improvement in the modules "Satisfaction with Breast" and "Psychosocial Well-being". The "Sexual Well-being" scale also improved. Only the module "Satisfaction with Breasts" significantly differed between groups; patients treated with the PureGraft fat exhibited better outcomes. The BCCT.core results did not significantly differ between the groups.
conclusionOne year postoperatively, the outcomes of the use of PureGraft bags or centrifugation to process fat for breast reconstruction after BCT did not differ. The unpredictability of the results following fatgrafting procedures is likely due to interindividual differences with yet-undisclosed causes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.