Evidence map›Paper›PMID 24898144›Full record

ArticleDiabetes2014

Effect of guanylate cyclase-C activity on energy and glucose homeostasis.

Denovan P Begg, Kris A Steinbrecher, Joram D Mul, Adam P Chambers, Rohit Kohli, April Haller, Mitchell B Cohen, Stephen C Woods, Randy J Seeley

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 42 citations in OpenAlex.

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  12. Activation of brown adipose tissue in diet-induced thermogenesis is GC-C dependent.Pflugers Archiv : European journal of physiology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Denovan P BeggMetabolic Diseases Institute, University of Cincinnati, Cincinnati, OH School of Psychology, University of New South Wales, Sydney, New South Wales, Australia d.begg@unsw.edu.au.
Kris A SteinbrecherDivision of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Joram D MulMetabolic Diseases Institute, University of Cincinnati, Cincinnati, OH.
Adam P ChambersMetabolic Diseases Institute, University of Cincinnati, Cincinnati, OH.
Rohit KohliDivision of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
April HallerMetabolic Diseases Institute, University of Cincinnati, Cincinnati, OH.
Mitchell B CohenDivision of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Stephen C WoodsMetabolic Diseases Institute, University of Cincinnati, Cincinnati, OH.
Randy J SeeleyMetabolic Diseases Institute, University of Cincinnati, Cincinnati, OH.
University of Cincinnati · USCincinnati Children's Hospital Medical Center · USUNSW Sydney · AU

Funding

REGULATORY RESPONSES TO POSITIVE ENERGY BALANCER01DK054080 · NIDDK · UNIVERSITY OF CINCINNATI · PI SEELEY, RANDY J. · 1997 to 2006
$1.6M
cGMP Metabolism in Resistance to Bacterial InfectionR21AI107274 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI STEINBRECHER, KRIS · 2013 to 2014
$371k
NIAID NIH HHS R21 AI107274NIDDK NIH HHS DK-54080NIDDK NIH HHS R01 DK054080
6 · The paper itself

Abstract

Uroguanylin is a gastrointestinal hormone primarily involved in fluid and electrolyte handling. It has recently been reported that prouroguanylin, secreted postprandially, is converted to uroguanylin in the brain and activates the receptor guanylate cyclase-C (GC-C) to reduce food intake and prevent obesity. We tested central nervous system administration of two GC-C agonists and found no significant reduction of food intake. We also carefully phenotyped mice lacking the GC-C receptor and found them to have normal body weight, adiposity, and glucose tolerance. Interestingly, uroguanylin knockout mice had a small but significant increase in body weight and adiposity that was accompanied by glucose intolerance. Our data indicate that the modest effects of uroguanylin on energy and glucose homeostasis are not mediated by central GC-C receptors.

Indexed as

AnimalsCyclic GMPEatingEnergy MetabolismGlucoseGuanylate CyclaseMaleMiceNatriuretic PeptidesRatsReceptors, EnterotoxinReceptors, Guanylate Cyclase-CoupledReceptors, PeptideCyclic GMPGlucoseGuanylate CyclaseGucy2c protein, mouseNatriuretic PeptidesReceptors, EnterotoxinReceptors, Guanylate Cyclase-CoupledReceptors, Peptideuroguanylin

Identifiers

PMID24898144
PMCPMC4207398
OpenAlexW2056762113

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.