ArticleEvolution; international journal of organic evolution2014
Fisher's geometric model with a moving optimum.
Article in Evolution; international journal of organic evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Article
- Effects of inbreeding on balancing selection: insights from Fisher's geometric model.Genetics · 2025Article
- Connections between sequential Bayesian inference and evolutionary dynamics.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Article
- Fisher's Geometric Model as a Tool to Study Speciation.Cold Spring Harbor perspectives in biology · 2024Review
- Evolutionary rescue on genotypic fitness landscapes.Journal of the Royal Society, Interface · 2023Article
- Phenotype Design Space Provides a Mechanistic Framework Relating Molecular Parameters to Phenotype Diversity Available for Selection.Journal of molecular evolution · 2023Article
- Genetic Architecture of Flowering Time Differs Between Populations With Contrasting Demographic and Selective Histories.Molecular biology and evolution · 2023Article
- Evolutionary repeatability of emergent properties of ecological communities.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- The geometry of evolutionary conflict.Proceedings. Biological sciences · 2023Article
- Using landscape genomics to delineate future adaptive potential for climate change in the Yosemite toad (Evolutionary applications · 2023Article
- The diverse effects of phenotypic dominance on hybrid fitness.Evolution; international journal of organic evolution · 2022Article
- Biological adaptation in light of the Lewontin-Williams (a)symmetry.Evolution; international journal of organic evolution · 2022Article
- Evolution in small steps and giant leaps.Evolution; international journal of organic evolution · 2022Review
- The geometry and genetics of hybridization.Evolution; international journal of organic evolution · 2020Article
- Evolutionary adaptation of high-diversity communities to changing environments.Ecology and evolution · 2020Article
- Article
- Why is cancer not more common? A changing microenvironment may help to explain why, and suggests strategies for anti-cancer therapy.Open biology · 2020Article
- Long-term evolutionary conflict, Sisyphean arms races, and power in Fisher's geometric model.Ecology and evolution · 2019Article
- Surfing on the seascape: Adaptation in a changing environment.Evolution; international journal of organic evolution · 2019Article
- Symbiont evolution during the free-living phase can improve host colonization.Microbiology (Reading, England) · 2019Article
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3 authors.
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Abstract
Fisher's geometric model has been widely used to study the effects of pleiotropy and organismic complexity on phenotypic adaptation. Here, we study a version of Fisher's model in which a population adapts to a gradually moving optimum. Key parameters are the rate of environmental change, the dimensionality of phenotype space, and the patterns of mutational and selectional correlations. We focus on the distribution of adaptive substitutions, that is, the multivariate distribution of the phenotypic effects of fixed beneficial mutations. Our main results are based on an "adaptive-walk approximation," which is checked against individual-based simulations. We find that (1) the distribution of adaptive substitutions is strongly affected by the ecological dynamics and largely depends on a single composite parameter γ, which scales the rate of environmental change by the "adaptive potential" of the population; (2) the distribution of adaptive substitution reflects the shape of the fitness landscape if the environment changes slowly, whereas it mirrors the distribution of new mutations if the environment changes fast; (3) in contrast to classical models of adaptation assuming a constant optimum, with a moving optimum, more complex organisms evolve via larger adaptive steps.
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