ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2014
Cannabinoids prevent the effects of a footshock followed by situational reminders on emotional processing.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 56 citations in OpenAlex.
- Cannabinoid 1 receptor availability in posttraumatic stress disorder: A positron emission tomography study.Translational psychiatry · 2025Article
- Cannabidiol Modulates Neuroinflammatory Markers in a PTSD Model Conducted on Female Rats.Biomolecules · 2024Article
- Synergistic antidepressant-like effect of citicoline and CB 1 agonist in male mice.Psychopharmacology · 2024Article
- Enhancing Endocannabinoid Signaling via β-Catenin in the Nucleus Accumbens Attenuates PTSD- and Depression-like Behavior of Male Rats.Biomedicines · 2022Article
- Repeated cocaine exposure prior to fear conditioning induces persistency of PTSD-like symptoms and enhancement of hippocampal and amygdala cell density in male rats.Brain structure & function · 2021Article
- Article
- Endocannabinoid System Components as Potential Biomarkers in Psychiatry.Frontiers in psychiatry · 2020Review
- Endocannabinoids, stress signaling, and the locus coeruleus-norepinephrine system.Neurobiology of stress · 2019Review
- Region- and time-dependent gene regulation in the amygdala and anterior cingulate cortex of a PTSD-like mouse model.Molecular brain · 2019Article
- Tempering aversive/traumatic memories with cannabinoids: a review of evidence from animal and human studies.Psychopharmacology · 2019Review
- Role of endocannabinoids in the hippocampus and amygdala in emotional memory and plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Enhancing Endocannabinoid Neurotransmission Augments The Efficacy of Extinction Training and Ameliorates Traumatic Stress-Induced Behavioral Alterations in Rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Changes in Gene Expression in the Locus Coeruleus-Amygdala Circuitry in Inhibitory Avoidance PTSD Model.Cellular and molecular neurobiology · 2018Article
- Cannabinoid Modulation of the Stressed Hippocampus.Frontiers in molecular neuroscience · 2017Review
- Cannabinoids reverse the effects of early stress on neurocognitive performance in adulthood.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Cannabinoids and Glucocorticoids in the Basolateral Amygdala Modulate Hippocampal-Accumbens Plasticity After Stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Does Cannabis Cause, Exacerbate or Ameliorate Psychiatric Disorders? An Oversimplified Debate Discussed.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- An Overview of Translationally Informed Treatments for Posttraumatic Stress Disorder: Animal Models of Pavlovian Fear Conditioning to Human Clinical Trials.Biological psychiatry · 2015Review
- Drug discovery strategies that focus on the endocannabinoid signaling system in psychiatric disease.Expert opinion on drug discovery · 2015Review
- Toward a translational approach to targeting the endocannabinoid system in posttraumatic stress disorder: a critical review of preclinical research.Biological psychology · 2015Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Posttraumatic stress disorder (PTSD) can develop following exposure to a traumatic event. Hence, what we do in the first few hours after trauma exposure may alter the trajectory of PTSD. We examined whether cannabinoids can prevent the effects of a single footshock followed by situational reminders (SRs) on emotional processing. Rats were exposed to a footshock (1.5 mA, 10 s) on day 1 followed by exposure to SRs of the shock on days 3 and 5. The CB1/2 receptor agonist WIN55,212-2 or vehicle were injected intraperitoneally 2 h after the shock. After 1 week, PTSD-like symptoms were examined. Exposure to SRs exacerbated the effects of the shock as rats exposed to shock and SRs, but not shock alone, showed impaired extinction of the traumatic event, impaired plasticity in the hippocmapal-accumbens pathway, enhanced latency to startle, and altered expression of CB1 receptors (CB1r) and glucocorticoid receptors (GRs) in the CA1, basolateral amygdala (BLA) and prefrontal cortex (PFC). WIN55,212-2 prevented the effects of the shock and SRs on extinction, plasticity, and startle response. WIN55,212-2 normalized the shock/SR-induced upregulation in CB1r in the PFC, and CA1 and GRs in the CA1, with no effect on BLA downregulation of CB1r and GRs. Shock and SRs caused lasting (1 week) alterations in emotional processing associated with changes in GR and CB1r expression in brain areas related to PTSD. WIN55,212-2 administered after trauma exposure prevented these alterations via PFC- and CA1-CB1r and CA1-GRs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.