ArticleBMC genomics2014
Genome-wide analysis of alternative splicing of pre-mRNA under salt stress in Arabidopsis.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers.
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Who cites it
140 citing papers in PubMed, 305 citations in OpenAlex.
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- Transcriptomic and alternative splicing reprogramming by low-dose gamma irradiation in tomato under ToBRFV infection.Biochemistry and biophysics reports · 2026Article
- Differential splicing fine-tunes guard cell gene expression and is required for drought tolerance in Arabidopsis thaliana.The Plant journal : for cell and molecular biology · 2026Article
- Transcript isoforms and alternative splicing in polyploid Brassica napus under heat and cold stress.Annals of botany · 2026Article
- Conservation and Remodeling of Alternative Splicing Landscapes in the Evolution ofPlants (Basel, Switzerland) · 2025Article
- Physio-biochemical and transcriptomic analysis reveals underlying mechanism of Cys-induced amelioration of Cd toxicity in maize.Physiology and molecular biology of plants : an international journal of functional plant biology · 2025Article
- Molecular Mechanisms of Plant Stress Memory: Roles of Non-Coding RNAs and Alternative Splicing.Plants (Basel, Switzerland) · 2025Review
- Transcriptome Analysis Between Parents and Offspring Revealed the Early Salt Tolerance Mechanism of Rice NGY1.Rice (New York, N.Y.) · 2025Article
- The Regulatory Roles of RNA-Binding Proteins in Plant Salt Stress Response.Plants (Basel, Switzerland) · 2025Review
- Exploring Alternative Splicing in Response to Salinity: A Tissue-Level Comparative Analysis UsingPlants (Basel, Switzerland) · 2025Article
- Genome-wide identification ofPeerJ · 2025Article
- Genome-wide identification of SHMT family genes in alfalfa (Medicago sativa) and its functional analyses under various abiotic stresses.BMC genomics · 2024Article
- Exploring salt tolerance mechanisms using machine learning for transcriptomic insights: case study inHorticulture research · 2024Article
- DEAD-Box RNA Helicase Family in Physic Nut (Plants (Basel, Switzerland) · 2024Article
- Responsive Alternative Splicing Events ofInternational journal of molecular sciences · 2024Article
- Alternative splicing responses to salt stress inFrontiers in genetics · 2024Article
- Transcriptome analysis reveals the effect of cold storage time on the expression of genes related to oxidative metabolism in Chinese black truffle.Frontiers in nutrition · 2024Article
- RNA-seq analysis reveals transcriptome reprogramming and alternative splicing during early response to salt stress in tomato root.Frontiers in plant science · 2024Article
- Comparative transcriptomic analyses of diploid and tetraploid citrus reveal how ploidy level influences salt stress tolerance.Frontiers in plant science · 2024Article
- The Splicing Factor SR45 Negatively Regulates Anthocyanin Accumulation under High-Light Stress inLife (Basel, Switzerland) · 2023Article
80 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlternative splicing (AS) of precursor mRNA (pre-mRNA) is an important gene regulation process that potentially regulates many physiological processes in plants, including the response to abiotic stresses such as salt stress.
resultsTo analyze global changes in AS under salt stress, we obtained high-coverage (~200 times) RNA sequencing data from Arabidopsis thaliana seedlings that were treated with different concentrations of NaCl. We detected that ~49% of all intron-containing genes were alternatively spliced under salt stress, 10% of which experienced significant differential alternative splicing (DAS). Furthermore, AS increased significantly under salt stress compared with under unstressed conditions. We demonstrated that most DAS genes were not differentially regulated by salt stress, suggesting that AS may represent an independent layer of gene regulation in response to stress. Our analysis of functional categories suggested that DAS genes were associated with specific functional pathways, such as the pathways for the responses to stresses and RNA splicing. We revealed that serine/arginine-rich (SR) splicing factors were frequently and specifically regulated in AS under salt stresses, suggesting a complex loop in AS regulation for stress adaptation. We also showed that alternative splicing site selection (SS) occurred most frequently at 4 nucleotides upstream or downstream of the dominant sites and that exon skipping tended to link with alternative SS.
conclusionsOur study provided a comprehensive view of AS under salt stress and revealed novel insights into the potential roles of AS in plant response to salt stress.
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