ArticleJournal of pediatric gastroenterology and nutrition2014
Health-related quality of life over time in children with eosinophilic esophagitis and their families.
Article in Journal of pediatric gastroenterology and nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Assessing the psychological effects of eosinophilic esophagitis: a study on anxiety, self-concept, and depression in pediatric patients.European journal of pediatrics · 2026Article
- Eosinophilic gastrointestinal diseases.Nature reviews. Disease primers · 2026Review
- Eosinophilic esophagitis: Examining the impact of disease.Journal of food allergy · 2025Review
- A multidisciplinary approach to eosinophilic esophagitis management.Journal of food allergy · 2025Review
- [Eosinophilic esophagitis-an underestimated food allergy?]Dermatologie (Heidelberg, Germany) · 2025Review
- Eosinophilic Esophagitis: Prevalence, Diagnosis, and Treatment in Childhood and Adulthood.Deutsches Arzteblatt international · 2025Review
- Disease Burden and Spectrum of Symptoms that Impact Quality of Life in Pediatric Patients with Eosinophilic Esophagitis.Gastro hep advances · 2024Review
- The Cellie Coping Kit for children with Eosinophilic Esophagitis: Feasibility, acceptability, and preliminary outcomes.Journal of child health care : for professionals working with children in the hospital and community · 2023Article
- Child, Parent, and Family Adjustment for Patients Followed in a Multidisciplinary Spina Bifida Clinic.Topics in spinal cord injury rehabilitation · 2022Article
- Measurement of Quality-of-Life Outcomes in Pediatric and Young Adult Patients Treated for Eosinophilic Esophagitis.Cureus · 2022Article
- Generic Measures of Quality of Life Are Not Correlated with Disease Activity in Eosinophilic Esophagitis.Digestive diseases and sciences · 2021Article
- Strategy for Food Reintroduction Following Empiric Elimination and Elemental Dietary Therapy in the Treatment of Eosinophilic Gastrointestinal Disorders.Current gastroenterology reports · 2020Review
- Health Service Use and Treatment Choices for Pediatric Eosinophilic Esophagitis: Findings From a Cross-Sectional Survey of Australian Carers.Frontiers in pediatrics · 2020Article
- Anxiety and Depression in Eosinophilic Esophagitis: A Scoping Review and Recommendations for Future Research.Journal of asthma and allergy · 2019Article
- Solute carrier family 9, subfamily A, member 3 (SLC9A3)/sodium-hydrogen exchanger member 3 (NHE3) dysregulation and dilated intercellular spaces in patients with eosinophilic esophagitis.The Journal of allergy and clinical immunology · 2018Article
- Psychosocial Mediators of Change and Patient Selection Factors in Oral Immunotherapy Trials.Clinical reviews in allergy & immunology · 2018Review
- A diagnosis of eosinophilic esophagitis is associated with increased life insurance premiums.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2018Article
- Assessing Adherence and Barriers to Long-Term Elimination Diet Therapy in Adults with Eosinophilic Esophagitis.Digestive diseases and sciences · 2018Article
- Disease-Related Predictors of Health-Related Quality of Life in Youth With Eosinophilic Esophagitis.Journal of pediatric psychology · 2018Article
- Evidence of Disturbed Sleep in Children With Eosinophilic Esophagitis and Persistent Epigastric Pain.Journal of pediatric psychology · 2018Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
objectivesExisting treatments for pediatric eosinophilic esophagitis (EoE) effectively reduce inflammation. The impact of treatment on health-related quality of life (HRQoL) over time for pediatric patients with EoE and their families, however, has not been systematically assessed. We hypothesized that individualized multidisciplinary treatment would improve both child and family HRQoL over time, with improvements associated with decreased symptom severity.
methodsChildren with EoE treated in 4 tertiary care centers were enrolled. Baseline assessments occurred at the time of patients' first evaluation; follow-up assessments occurred at 2 and 6 months after baseline. Presence and severity of 8 EoE symptoms were measured. HRQoL was measured with the Pediatric Quality of Life Inventory parent proxy report, child self-report (CR), and Family Impact Module (FIM). Statistical analyses used mixed-effects modeling to test changes over time for child and family HRQoL.
resultsNinety-seven children were enrolled (ages 2-18 years, mean age 7.7 years ± 4.8, 78% boys, 80% white). Baseline mean symptom number was 3.5 (standard deviation 2.3), and symptom severity was 5.5 (standard deviation, 4.5). HRQoL scores were significantly related to symptom scores (P < 0.001). EoE symptom severity decreased during the study (P = 0.03). Pediatric Quality of Life Inventory parent proxy Total and FIM Total scores improved from baseline to 6 months (respectively, adjusted means 78.4 vs 81.0, P = 0.0006; 68.9 vs 70.1, P = 0.03). Interactions with baseline symptom severity revealed that subjects with lowest symptom severity showed the most improved HRQoL scores (P = 0.0013).
conclusionsHRQoL improved during the course of evaluation and treatment, with positive changes being strongest for patients with less symptom severity at baseline.
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