Evidence map›Paper›PMID 24896815›Full record

ArticlePloS one2014

Effect of female genital schistosomiasis and anti-schistosomal treatment on monocytes, CD4+ T-cells and CCR5 expression in the female genital tract.

Elisabeth Kleppa, Veron Ramsuran, Siphosenkosi Zulu, Gunn Hege Karlsen, Alfred Bere, Jo-Ann S Passmore, Patricia Ndhlovu, Kristine Lillebø, Sigve D Holmen, Mathias Onsrud and 4 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01154907 (Prevention of HIV and Improved Diagnosis of Adolescent Genital Disease in Bilharzia Endemic KwaZulu-Natal, South Africa), which is not on this map. Cited by 36 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 6 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01154907 unknown statusnot on this map

Prevention of HIV and Improved Diagnosis of Adolescent Genital Disease in Bilharzia Endemic KwaZulu-Natal, South Africa

TypeobservationalSponsorOslo University HospitalRan2010 to 2021Enrolled6,500ConditionsUro-genital SchistosomiasisArmsPraziquantel
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 6 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
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  3. Association of schistosomiasis and HIV infections: A systematic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
    Pooled it
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  5. Interactions ofThe American journal of tropical medicine and hygiene · 2020
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  14. Open forum infectious diseases · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 5 countries.

Elisabeth KleppaNorwegian Centre for Imported and Tropical Diseases, Department of Infectious Diseases, Oslo University Hospital (OUH), Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway.
Veron RamsuranHIV Pathogenesis Programme, Nelson R Mandela School of Medicine, University of KwaZulu-Natal (UKZN), Durban, South Africa.
Siphosenkosi ZuluSchool of Public Health Medicine, Nelson R Mandela School of Medicine, UKZN, Durban, South Africa.
Gunn Hege KarlsenAarhus University, Aarhus, Denmark.
Alfred BereEmory Vaccine Center, Emory University, Atlanta, Georgia, United States of America.
Jo-Ann S PassmoreDivision of Medical Virology, IDM, University of Cape Town, Cape Town, South Africa.
Patricia NdhlovuImperial College, London, United Kingdom.
Kristine LillebøNorwegian Centre for Imported and Tropical Diseases, Department of Infectious Diseases, Oslo University Hospital (OUH), Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway.
Sigve D HolmenNorwegian Centre for Imported and Tropical Diseases, Department of Infectious Diseases, Oslo University Hospital (OUH), Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway.
Mathias OnsrudDepartment of Gynaecology, OUH, Oslo, Norway.
Svein Gunnar GundersenResearch Unit, Sorlandet Hospital, Kristiansand, Norway; Centre for Development Studies, University of Agder, Kristiansand, Norway.
Myra TaylorSchool of Public Health Medicine, Nelson R Mandela School of Medicine, UKZN, Durban, South Africa.
Eyrun F KjetlandNorwegian Centre for Imported and Tropical Diseases, Department of Infectious Diseases, Oslo University Hospital (OUH), Oslo, Norway; School of Public Health Medicine, Nelson R Mandela School of Medicine, UKZN, Durban, South Africa.
Thumbi Ndung'uHIV Pathogenesis Programme, Nelson R Mandela School of Medicine, University of KwaZulu-Natal (UKZN), Durban, South Africa.
Oslo University Hospital · NOUniversity of KwaZulu-Natal · ZAAarhus University · DKEmory University · USImperial College London · GBSørlandet Sykehus · NOUniversity of Cape Town · ZAUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSchistosoma haematobium is a waterborne parasite that may cause female genital schistosomiasis (FGS), characterized by genital mucosal lesions. There is clinical and epidemiological evidence for a relationship between FGS and HIV. We investigated the impact of FGS on HIV target cell density and expression of the HIV co-receptor CCR5 in blood and cervical cytobrush samples. Furthermore we evaluated the effect of anti-schistosomal treatment on these cell populations.

designThe study followed a case-control design with post treatment follow-up, nested in an on-going field study on FGS.

methodsBlood and cervical cytobrush samples were collected from FGS negative and positive women for flow cytometry analyses. Urine samples were investigated for schistosome ova by microscopy and polymerase chain reaction (PCR).

resultsFGS was associated with a higher frequency of CD14+ cells (monocytes) in blood (11.5% in FGS+ vs. 2.2% in FGS-, p = 0.042). Frequencies of CD4+ cells expressing CCR5 were higher in blood samples from FGS+ than from FGS- women (4.7% vs. 1.5%, p = 0.018). The CD14+ cell population decreased significantly in both compartments after anti-schistosomal treatment (p = 0.043). Although the frequency of CD4+ cells did not change after treatment, frequencies of CCR5 expression by CD4+ cells decreased significantly in both compartments (from 3.4% to 0.5% in blood, p = 0.036; and from 42.4% to 5.6% in genital samples, p = 0.025).

conclusionsThe results support the hypothesis that FGS may increase the risk of HIV acquisition, not only through damage of the mucosal epithelial barrier, but also by affecting HIV target cell populations, and that anti-schistosomal treatment can modify this.

Indexed as

Schistosoma haematobiumAdolescentAdultAnimalsCase-Control StudiesCD4-Positive T-LymphocytesCoinfectionFemaleGene ExpressionGenital Diseases, FemaleGenitalia, FemaleHumansImmunophenotypingMonocytesPhenotypePraziquantelPraziquantelReceptors, CCR5

Identifiers

PMID24896815
PMCPMC4045760
OpenAlexW2068382969

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.