ArticleJournal of exposure science & environmental epidemiology
Infant toenails as a biomarker of in utero arsenic exposure.
Article in Journal of exposure science & environmental epidemiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Toenails as a biomarker of exposure to arsenic: A review.Environmental research · 2021Pooled it
- Toxic metals and urban oil and gas production in a Latina cohort in South Los Angeles, California.Journal of exposure science & environmental epidemiology · 2026Article
- Time-Varying Exposure to Element Mixtures and Children's Cognition at 5 Years of Age: Findings from the New Hampshire Birth Cohort Study.Environmental health perspectives · 2026Article
- Methodology for Biological Sample Collection, Processing, and Storage in the Newcastle 1000 Pregnancy Cohort: Protocol for a Longitudinal, Prospective Population-Based Study in Australia.JMIR research protocols · 2024Article
- Associations of Perinatal Metal and Metalloid Exposures with Early Child Behavioral Development Over Time in the New Hampshire Birth Cohort Study.Exposure and health · 2024Article
- Assessing the feasibility of using toenails as biomarkers for estimating inorganic arsenic exposure in Japanese adults.Environmental health and preventive medicine · 2024Article
- Metals and per- and polyfluoroalkyl substances mixtures and birth outcomes in the New Hampshire Birth Cohort Study: Beyond single-class mixture approaches.Chemosphere · 2023Article
- Bacterial Modification of the Association Between Arsenic and Autism-Related Social Behavior Scores.Exposure and health · 2023Article
- Metal Exposures in Residents Living Near an Urban Oil Drilling Site in Los Angeles, California.Environmental science & technology · 2022Article
- Associations of maternal urinary arsenic concentrations during pregnancy with childhood cognitive abilities: The HOME study.International journal of hygiene and environmental health · 2022Article
- Parental metal exposures as potential risk factors for spina bifida in Bangladesh.Environment international · 2021Article
- Metal-mixtures in toenails of children living near an active industrial facility in Los Angeles County, California.Journal of exposure science & environmental epidemiology · 2021Article
- Periconceptional and prenatal exposure to metal mixtures in relation to behavioral development at 3 years of age.Environmental epidemiology (Philadelphia, Pa.) · 2020Article
- Nutrient-toxic element mixtures and the early postnatal gut microbiome in a United States longitudinal birth cohort.Environment international · 2020Article
- Maternal urinary cadmium, glucose intolerance and gestational diabetes in the New Hampshire Birth Cohort Study.Environmental research · 2019Article
- Prenatal exposure to metal mixture and sex-specific birth outcomes in the New Hampshire Birth Cohort Study.Environmental epidemiology (Philadelphia, Pa.) · 2019Article
- Prenatal lead exposure and elevated blood pressure in children.Environment international · 2018Article
- Article
- Urine and toenail cadmium levels in pregnant women: A reliability study.Environment international · 2018Article
- Opportunities and Challenges for Dietary Arsenic Intervention.Environmental health perspectives · 2018Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
A growing body of evidence suggests that in utero and early-life exposure to arsenic may have detrimental effects on children, even at the low to moderate levels common in the United States and elsewhere. In a sample of 170 mother-infant pairs from New Hampshire, we determined infant exposure to in utero arsenic by evaluating infant toenails as a biomarker using inductively coupled plasma mass spectrometry. Infant toenail arsenic concentration correlated with maternal postpartum toenail concentrations (Spearman's correlation coefficient 0.34). In adjusted linear models, a doubling of maternal toenail arsenic concentration was associated with a 53.8% increase in infant toenail arsenic concentration as compared with 20.4% for a doubling of maternal urine arsenic concentration. In a structural equation model, a doubling of the latent variable integrating maternal toenail and urine arsenic concentrations was associated with a 67.5% increase in infant toenail arsenic concentration. A similar correlation between infant and maternal postpartum toenail concentrations was observed in a validation cohort of 130 mother-infant pairs from Rhode Island. In utero exposure to arsenic occurs through maternal water and dietary sources, and infant toenails appear to be a reliable biomarker for estimating arsenic exposure during the critical window of gestation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.