ArticlePloS one2014
Modifiable risk factors for Alzheimer disease and subjective memory impairment across age groups.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- The Relationship Between Subjective Cognitive Decline and Cognitive Leisure Activity Engagement: A Systematic Review.The Gerontologist · 2024Pooled it
- Pooled it
- Subjective Cognitive Impairment and Affective Symptoms: A Systematic Review.The Gerontologist · 2016Pooled it
- Inflammation moderates the effects of lifestyle modification on neurocognition among individuals with resistant hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2023Trial
- A Comparative Single-Blind Randomized Controlled Trial With Language Training in People With Mild Cognitive Impairment.American journal of Alzheimer's disease and other dementias · 2019Trial
- Trial
- Diagnostic Value of Subjective Memory Complaints Assessed with a Single Item in Dominantly Inherited Alzheimer's Disease: Results of the DIAN Study.BioMed research international · 2015Trial
- Regulation of autophagy-mediated pathways by diet, physical activity, and sleep in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Cognitive Performance Among Older Adults with Subjective Cognitive Decline.Geriatrics (Basel, Switzerland) · 2025Article
- Exploring Task-Related EEG for Cross-Subject Early Alzheimer's Disease Susceptibility Prediction in Middle-Aged Adults Using Multitaper Spectral Analysis.Sensors (Basel, Switzerland) · 2024Article
- Finding Similarities in Differences Between Autistic Adults: Two Replicated Subgroups.Journal of autism and developmental disorders · 2024Article
- Intersectional Effects of Race and Educational Attainment on Memory Function of Middle-Aged and Older Adults With Alzheimer's Disease.Journal of racial and ethnic health disparities · 2024Article
- Neurophysiological markers of early cognitive decline in older adults: a mini-review of electroencephalography studies for precursors of dementia.Frontiers in aging neuroscience · 2024Review
- Association of cognitive impairment and diabetes on survival in Chinese older people with hypertension: a 10-year prospective study.BMC geriatrics · 2023Article
- Subjective memory in adults over 50 years of age: associations with affective and physiological markers of emotion regulation.Aging & mental health · 2022Article
- Subjective cognitive complaints and cardiovascular risk factors in older Mexican Americans: A cross-sectional study.Cerebral circulation - cognition and behavior · 2022Article
- Differences in Subjective Memory Impairment, Depressive Symptoms, Sleep, and Physical Activity in African American and Asian American Elderly.Brain sciences · 2021Article
- Episodic Memory Encoding and Retrieval in Face-Name Paired Paradigm: AnBrain sciences · 2021Article
- Subgroups in Late Adulthood Are Associated With Cognition and Wellbeing Later in Life.Frontiers in psychology · 2021Article
- Distinct Profile Differences in Subjective Cognitive Decline in the General Public Are Associated with Metacognition, Negative Affective Symptoms, Neuroticism, Stress, and Poor Quality of Life.Journal of Alzheimer's disease : JAD · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPrevious research has identified modifiable risk factors for Alzheimer's disease (AD) in older adults. Research is limited on the potential link between these risk factors and subjective memory impairment (SMI), which may precede AD and other dementias. Examination of these potential relationships may help identify those at risk for AD at a stage when interventions may delay or prevent further memory problems. The objective of this study was to determine whether risk factors for AD are associated with SMI among different age groups.
methodTrained interviewers conducted daily telephone surveys (Gallup-Healthways) of a representative community sample of 18,614 U.S. respondents, including 4,425 younger (age 18 to 39 years), 6,365 middle-aged (40 to 59 years), and 7,824 older (60 to 99 years) adults. The surveyors collected data on demographics, lifestyles, and medical information. Less education, smoking, hypertension, diabetes, less exercise, obesity and depression, and interactions among them, were examined for associations with SMI. Weighted logistic regressions and chi-square tests were used to calculate odds ratios and confidence intervals for SMI with each risk factor and pairwise interactions across age groups.
resultsDepression, less education, less exercise, and hypertension were significantly associated with SMI in all three age groups. Several interactions between risk factors were significant in younger and middle-aged adults and influenced their associations with SMI. Frequency of SMI increased with age and number of risk factors. Odds of having SMI increased significantly with just having one risk factor.
conclusionsThese results indicate that modifiable risk factors for AD are also associated with SMI, suggesting that these relationships occur in a broad range of ages and may be targeted to mitigate further memory problems. Whether modifying these risk factors reduces SMI and the eventual incidence of AD and other dementias later in life remains to be determined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.