ArticleAnalytical chemistry2014
Glucose oxidase-catalyzed growth of gold nanoparticles enables quantitative detection of attomolar cancer biomarkers.
Article in Analytical chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 178 citations in OpenAlex.
- Toward point-of-care cancer diagnostics: gold nanoparticle-based colorimetric sensors.RSC advances · 2026Review
- Analyte-mediated growth of gold nanoparticles for non-aggregation-based colorimetric detection of manganese(ii).RSC advances · 2026Article
- Ultrasensitive Electrochemical Immunoassays of IgG and CA125 Based on Glucose Oxidase-Catalyzed Signal Amplification with Gold Staining.Biosensors · 2025Article
- Golden eyes on pollutants: colorimetric detection of emerging contaminants with AuNPs.RSC advances · 2025Review
- Review
- Nanotechnology-leveraged CRISPR/Cas systems: icebreaking in trace cancer-related nucleic acids biosensing.Molecular cancer · 2025Review
- Colorimetric Immunoassays with Boronic Acid-Decorated, Peroxidase-like Metal-Organic Frameworks as the Carriers of Antibodies and Enzymes.Molecules (Basel, Switzerland) · 2024Article
- Point-of-Care Prostate Specific Antigen Testing: Examining Translational Progress toward Clinical Implementation.ACS sensors · 2023Review
- Gallic Acid-Triethylene Glycol Aptadendrimers Synthesis, Biophysical Characterization and Cellular Evaluation.Pharmaceutics · 2022Article
- Analyte-mediated formation and growth of nanoparticles for the development of chemical sensors and biosensors.Mikrochimica acta · 2022Review
- Shape dependent sensing potential of gold nanoparticles in etching based multicolorimetric plasmonic-ELISA.Nanoscale advances · 2022Article
- Cascade reaction networks within audible sound induced transient domains in a solution.Nature communications · 2022Article
- Wound microenvironment-responsive glucose consumption and hydrogen peroxide generation synergistic with azithromycin for diabetic wounds healing.Theranostics · 2022Article
- Colorimetric Detection of Organophosphate Pesticides Based on Acetylcholinesterase and Cysteamine Capped Gold Nanoparticles as Nanozyme.Sensors (Basel, Switzerland) · 2021Article
- Detection of Lysyl Oxidase Activity in Tumor Extracellular Matrix Using Peptide-Functionalized Gold Nanoprobes.Cancers · 2021Article
- Modulating the Thermoresponse of Polymer-Protein Conjugates with Hydrogels for Controlled Release.Polymers · 2021Article
- Multiplexed Nanobiosensors: Current Trends in Early Diagnostics.Sensors (Basel, Switzerland) · 2020Review
- The Basic Properties of Gold Nanoparticles and their Applications in Tumor Diagnosis and Treatment.International journal of molecular sciences · 2020Review
- Self-activatedTheranostics · 2020Article
- Signal amplification in immunoassays by using noble metal nanoparticles: a review.Mikrochimica acta · 2019Review
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
Ultrasensitive and quantitative detection of cancer biomarkers is an unmet challenge because of their ultralow concentrations in clinical samples. Although gold nanoparticle (AuNP)-based immunoassays offer high sensitivity, they were unable to quantitatively detect targets of interest most likely due to their very narrow linear ranges. This article describes a quantitative colorimetric immunoassay based on glucose oxidase (GOx)-catalyzed growth of 5 nm AuNPs that can detect cancer biomarkers from attomolar to picomolar levels. In addition, the limit of detection (LOD) of prostate-specific antigen (PSA) of this approach (93 aM) exceeds that of commercial enzyme-linked immunosorbent assay (ELISA) (6.3 pM) by more than 4 orders of magnitude. The emergence of red or purple color based on enzyme-catalyzed growth of 5 nm AuNPs in the presence of target antigen is particularly suitable for point-of-care (POC) diagnostics in both resource-rich and resource-limited settings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.