ArticleBiophysical journal2014
Platelet dynamics in three-dimensional simulation of whole blood.
Article in Biophysical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 101 citations in OpenAlex.
- Lattice Boltzmann simulation of deformable fluid-filled bodies: progress and perspectives.Soft matter · 2024Review
- Decoding thrombosis through code: a review of computational models.Journal of thrombosis and haemostasis : JTH · 2024Review
- A cell-and-plasma numerical model reveals hemodynamic stress and flow adaptation in zebrafish microvessels after morphological alteration.PLoS computational biology · 2023Article
- A Multiscale Model for Shear-Mediated Platelet Adhesion Dynamics: Correlating In Silico with In Vitro Results.Annals of biomedical engineering · 2023Article
- Modeling the Mechanical Microenvironment of Coiled Cerebral Aneurysms.Journal of biomechanical engineering · 2023Article
- Article
- Mitigating challenges and expanding the future of vascular tissue engineering-are we there yet?Frontiers in physiology · 2022Article
- Shear induced diffusion of platelets revisited.Frontiers in physiology · 2022Article
- Review
- Margination of Platelet-Sized Particles in the Red Blood Cell Suspension Flow through Square Microchannels.Micromachines · 2021Article
- Thrombosis and Hemodynamics: external and intrathrombus gradients.Current opinion in biomedical engineering · 2021Article
- Digital blood in massively parallel CPU/GPU systems for the study of platelet transport.Interface focus · 2021Article
- Vascular Nanomedicine: Current Status, Opportunities, and Challenges.Seminars in thrombosis and hemostasis · 2020Review
- Flow-induced segregation and dynamics of red blood cells in sickle cell disease.Physical review fluids · 2020Article
- Platelet Dynamics and Hemodynamics of Cerebral Aneurysms Treated with Flow-Diverting Stents.Annals of biomedical engineering · 2020Article
- Lattice Boltzmann methods and active fluids.The European physical journal. E, Soft matter · 2019Review
- In Vitro Measurement and Modeling of Platelet Adhesion on VWF-Coated Surfaces in Channel Flow.Biophysical journal · 2019Article
- Red Blood Cells: Chasing Interactions.Frontiers in physiology · 2019Review
- Quantifying Platelet Margination in Diabetic Blood Flow.Biophysical journal · 2018Article
- Antimargination of Microparticles and Platelets in the Vicinity of Branching Vessels.Biophysical journal · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
A high-fidelity computational model using a 3D immersed boundary method is used to study platelet dynamics in whole blood. We focus on the 3D effects of the platelet-red blood cell (RBC) interaction on platelet margination and near-wall dynamics in a shear flow. We find that the RBC distribution in whole blood becomes naturally anisotropic and creates local clusters and cavities. A platelet can enter a cavity and use it as an express lane for a fast margination toward the wall. Once near the wall, the 3D nature of the platelet-RBC interaction results in a significant platelet movement in the transverse (vorticity) direction and leads to anisotropic platelet diffusion within the RBC-depleted zone or cell-free layer (CFL). We find that the anisotropy in platelet motion further leads to the formation of platelet clusters, even in the absence of any platelet-platelet adhesion. The transverse motion, and the size and number of the platelet clusters are observed to increase with decreasing CFL thickness. The 3D nature of the platelet-RBC collision also induces fluctuations in off-shear plane orientation and, hence, a rotational diffusion of the platelets. Although most marginated platelets are observed to tumble just outside the RBC-rich zone, platelets further inside the CFL are observed to flow with an intermittent dynamics that alters between sliding and tumbling, as a result of the off-shear plane rotational diffusion, bringing them even closer to the wall. To our knowledge, these new findings are based on the fundamentally 3D nature of the platelet-RBC interaction, and they underscore the importance of using cellular-scale 3D models of whole blood to understand platelet margination and near-wall platelet dynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.