ArticleBiophysical journal2014
Motor regulation results in distal forces that bend partially disintegrated Chlamydomonas axonemes into circular arcs.
Article in Biophysical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Structural determination and modeling of ciliary microtubules.Acta crystallographica. Section D, Structural biology · 2024Review
- Structure and Mechanics of Dynein Motors.Annual review of biophysics · 2021Review
- Structure of a microtubule-bound axonemal dynein.Nature communications · 2021Article
- Intracellular coupling modulates biflagellar synchrony.Journal of the Royal Society, Interface · 2021Article
- RETRACTED: Human sperm uses asymmetric and anisotropic flagellar controls to regulate swimming symmetry and cell steering.Science advances · 2020Article
- Cilia oscillations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Automated identification of flagella from videomicroscopy via the medial axis transform.Scientific reports · 2019Article
- Automatic optimal filament segmentation with sub-pixel accuracy using generalized linear models and B-spline level-sets.Medical image analysis · 2016Article
- Coordinated beating of algal flagella is mediated by basal coupling.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Dynamic curvature regulation accounts for the symmetric and asymmetric beats of Chlamydomonas flagella.eLife · 2016Article
- Engaging the "clutch" to move forward.Biophysical journal · 2014Article
- Dynein regulation: going into circles can set things straight.Biophysical journal · 2014Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bending of cilia and flagella is driven by forces generated by dynein motor proteins. These forces slide adjacent microtubule doublets within the axoneme, the motile cytoskeletal structure. To create regular, oscillatory beating patterns, the activities of the axonemal dyneins must be coordinated both spatially and temporally. It is thought that coordination is mediated by stresses or strains, which build up within the moving axoneme, and somehow regulate dynein activity. During experimentation with axonemes subjected to mild proteolysis, we observed pairs of doublets associating with each other and forming bends with almost constant curvature. By modeling the statics of a pair of filaments, we show that the activity of the motors concentrates at the distal tips of the doublets. Furthermore, we show that this distribution of motor activity accords with models in which curvature, or curvature-induced normal forces, regulates the activity of the motors. These observations, together with our theoretical analysis, provide evidence that dynein activity can be regulated by curvature or normal forces, which may, therefore, play a role in coordinating the beating of cilia and flagella.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.