ArticleBiophysical journal2014
Dynamics of cell shape and forces on micropatterned substrates predicted by a cellular Potts model.
Article in Biophysical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44 citing papers in PubMed.
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- Cellular geometry and epithelial-mesenchymal plasticity intersect with PIEZO1 in breast cancer cells.Communications biology · 2024Article
- Modelling cell shape in 3D structured environments: A quantitative comparison with experiments.PLoS computational biology · 2024Article
- Hybrid cellular Potts and bead-spring modeling of cells in fibrous extracellular matrix.Biophysical journal · 2023Article
- Printing channels with millimeter-scale curvature and deciphering their effect on the proliferation, morphology, orientation, and migration of M-22 cells.International journal of bioprinting · 2023Article
- Anisotropy profoundly alters stress fields within contractile cells and cell aggregates.Biomechanics and modeling in mechanobiology · 2022Article
- Mechanical strain stimulates COPII-dependent secretory trafficking via Rac1.The EMBO journal · 2022Article
- Intrinsic cell rheology drives junction maturation.Nature communications · 2022Article
- High-Throughput Methods in the Discovery and Study of Biomaterials and Materiobiology.Chemical reviews · 2021Review
- Articular Chondrocyte Phenotype Regulation through the Cytoskeleton and the Signaling Processes That Originate from or Converge on the Cytoskeleton: Towards a Novel Understanding of the Intersection between Actin Dynamics and Chondrogenic Function.International journal of molecular sciences · 2021Review
- Cell Shape and Durotaxis Explained from Cell-Extracellular Matrix Forces and Focal Adhesion Dynamics.iScience · 2020Article
- A Lock Free Approach To Parallelize The Cellular Potts Model: Application To Ductal Carcinoma In Situ.Journal of integrative bioinformatics · 2020Article
- Area and Geometry Dependence of Cell Migration in Asymmetric Two-State Micropatterns.Biophysical journal · 2020Article
- Mechanisms of endothelial cell coverage by pericytes: computational modelling of cell wrapping andJournal of the Royal Society, Interface · 2020Article
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2 authors.
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Abstract
Micropatterned substrates are often used to standardize cell experiments and to quantitatively study the relation between cell shape and function. Moreover, they are increasingly used in combination with traction force microscopy on soft elastic substrates. To predict the dynamics and steady states of cell shape and forces without any a priori knowledge of how the cell will spread on a given micropattern, here we extend earlier formulations of the two-dimensional cellular Potts model. The third dimension is treated as an area reservoir for spreading. To account for local contour reinforcement by peripheral bundles, we augment the cellular Potts model by elements of the tension-elasticity model. We first parameterize our model and show that it accounts for momentum conservation. We then demonstrate that it is in good agreement with experimental data for shape, spreading dynamics, and traction force patterns of cells on micropatterned substrates. We finally predict shapes and forces for micropatterns that have not yet been experimentally studied.
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