ArticleTheScientificWorldJournal2014
Caenorhabditis elegans as model system in pharmacology and toxicology: effects of flavonoids on redox-sensitive signalling pathways and ageing.
Article in TheScientificWorldJournal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
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- AntioxidantAntioxidants (Basel, Switzerland) · 2022Article
- Phytochemical Profiling of the Leaf Extract ofOxidative medicine and cellular longevity · 2022Article
- The Hallmarks of Flavonoids in Cancer.Molecules (Basel, Switzerland) · 2021Review
- Caffeic and Dihydrocaffeic Acids Promote Longevity and Increase Stress Resistance inMolecules (Basel, Switzerland) · 2021Article
- Benzo[a]pyrene and Caenorhabditis elegans: defining the genotoxic potential in an organism lacking the classical CYP1A1 pathway.Archives of toxicology · 2021Article
- Extracts of the Tiger Milk Mushroom (Pharmaceuticals (Basel, Switzerland) · 2021Article
- Food Processing Technologies to Develop Functional Foods With Enriched Bioactive Phenolic Compounds in Cereals.Frontiers in plant science · 2021Review
- Flavonoids mitigate neurodegeneration in agedFood science & nutrition · 2020Article
- Phenolic Compounds Reduce the Fat Content inPharmaceuticals (Basel, Switzerland) · 2020Article
- Optimization in continuous phase-transition extraction of crude flavonoids from finger citron fruit and evaluation on their antiaging activities.Food science & nutrition · 2020Article
- Protective Effect of Semisynthetic and Natural Flavonoid on Aged Rat Microglia-enriched Cultures.Neurotoxicity research · 2019Article
- Antioxidant Activity of an Aqueous Leaf Extract fromMolecules (Basel, Switzerland) · 2019Article
- Epicatechin modulates stress-resistance in C. elegans via insulin/IGF-1 signaling pathway.PloS one · 2019Article
- Pasteurized Orange Juice Rich in Carotenoids ProtectsOxidative medicine and cellular longevity · 2019Article
- Aiweixin, a Traditional Uyghur Medicinal Formula, Extends the Lifespan ofEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Isoxanthohumol, a constituent of hop (Humulus lupulus L.), increases stress resistance in Caenorhabditis elegans dependent on the transcription factor DAF-16.European journal of nutrition · 2016Article
- Longevity extension by phytochemicals.Molecules (Basel, Switzerland) · 2015Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flavonoids are secondary plant compounds that mediate diverse biological activities, for example, by scavenging free radicals and modulating intracellular signalling pathways. It has been shown in various studies that distinct flavonoid compounds enhance stress resistance and even prolong the life span of organisms. In the last years the model organism C. elegans has gained increasing importance in pharmacological and toxicological sciences due to the availability of various genetically modified nematode strains, the simplicity of modulating genes by RNAi, and the relatively short life span. Several studies have been performed demonstrating that secondary plant compounds influence ageing, stress resistance, and distinct signalling pathways in the nematode. Here we present an overview of the modulating effects of different flavonoids on oxidative stress, redox-sensitive signalling pathways, and life span in C. elegans introducing the usability of this model system for pharmacological and toxicological research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.