ArticleBioMed research international2014
Antidepressant-like effect of Ilex paraguariensis in rats.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 35 citations in OpenAlex.
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- Caffeinated non-alcoholic beverages on the postpartum mental health related to the COVID-19 pandemic by a cross-sectional study in Argentina.Human nutrition & metabolism · 2023Article
- Anti-hypercholesterolemic potential of diet supplemented withJournal of diabetes and metabolic disorders · 2020Article
- Isoflavones prevent oxidative stress and inhibit the activity of the enzyme monoamine oxidase in vitro.Molecular biology reports · 2019Article
- Effect of dietary supplement from mono-culture fermentation ofFood science & nutrition · 2018Article
- Resveratrol Protects Against Vacuous Chewing Movements Induced by Chronic Treatment with Fluphenazine.Neurochemical research · 2017Article
- Differential protection of black-seed oil on econucleotidase, cholinesterases and aminergic catabolizing enzyme in haloperidol-induced neuronal damage of male rats.Therapeutic advances in drug safety · 2016Article
- Behavioral and neurochemical effects induced by reserpine in mice.Psychopharmacology · 2016Article
- Hyperhomocysteinemia is a result, rather than a cause, of depression under chronic stress.PloS one · 2014Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we investigated the possible antidepressant-like effect of I. paraguariensis in rats. Rats were treated for four weeks with an aqueous extract of I. paraguariensis in drinking water, following the traditional preparation of this beverage. After the period of treatment, behavioral (elevated plus-maze, open field test, and forced swimming test) and biochemical parameters (lipid peroxidation assay, thiol content, vitamin C levels, and monoamine oxidase activity) were evaluated. Animals were also analyzed on forced swimming test after 24 hours of I. paraguariensis intake. An additional group was injected with selegiline 24 hours and 30 minutes before forced swimming test as positive control. HPLC analysis revealed the profile of I. paraguariensis extract. I. paraguariensis reduced the immobility time on forced swimming test without significant changes in locomotor activity in the open field test. Any anxiolytic/anxiogenic effect of I. paraguariensis was observed in rats through the elevated plus-maze test. The antidepressant-like effect of I. paraguariensis was not accompanied by inhibitory effect on monoamine oxidase activity. There were no significant alterations on lipid peroxidation, thiol content, and vitamin C levels among the groups. In conclusion, aqueous extract of I. paraguariensis decreases the time of immobility in rats suggesting an antidepressant-like effect.
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