ArticleBioMed research international2014
Quantitative evaluation of the severity of acute illness in adult patients with tick-borne encephalitis.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Long-Term Outcomes in Adult Patients with Tick-Borne Encephalitis in Latvia.Pathogens (Basel, Switzerland) · 2026Article
- Evaluation of CXCL12 Diagnostic Performance in Tick-Borne Encephalitis and Other Central Nervous System Infections.International journal of molecular sciences · 2026Article
- Review
- Article
- The Factors Associated with the Blood-Brain Barrier Dysfunction in Tick-Borne Encephalitis.International journal of molecular sciences · 2025Article
- Presentation, Management, and Outcome of Tick-Borne Encephalitis in Patients Referred to Infectious Diseases or Neurology.Journal of clinical medicine · 2024Article
- Poor virus-specific T-cell responses early after tick-borne encephalitis virus infection correlate with disease severity.Emerging microbes & infections · 2024Article
- Tick-borne encephalitis vaccine breakthrough infections induce aberrant T cell and antibody responses to non-structural proteins.NPJ vaccines · 2024Article
- TaqMan qPCR and IgM Detection in Samples of Patients with Tick-Borne Encephalitis Virus Infection in Northeast China.International journal of general medicine · 2024Article
- The Role of Chitinase 3-Like-1 (YKL-40) and Proinflammatory Biomarkers in the Pathogenesis of Pediatric Tick-Borne Encephalitis in a Polish Cohort.Journal of inflammation research · 2024Article
- The Detectability of the Viral RNA in Blood and Cerebrospinal Fluid of Patients with Tick-Borne Encephalitis.International journal of molecular sciences · 2022Article
- Clinical Characteristics of Patients with Tick-Borne Encephalitis (TBE): A European Multicentre Study from 2010 to 2017.Microorganisms · 2021Article
- Comparison of Clinical, Laboratory and Immune Characteristics of the Monophasic and Biphasic Course of Tick-Borne Encephalitis.Microorganisms · 2021Article
- Low Virus-Specific IgG Antibodies in Adverse Clinical Course and Outcome of Tick-Borne Encephalitis.Microorganisms · 2021Article
- Antibiotic Use and Long-Term Outcome in Patients with Tick-Borne Encephalitis and Co-Infection withJournal of clinical medicine · 2019Article
- Inflammatory Immune Responses in the Pathogenesis of Tick-Borne Encephalitis.Journal of clinical medicine · 2019Article
- Tick-borne encephalitis virus infections in Germany. Seasonality and in-year patterns. A retrospective analysis from 2001-2018.PloS one · 2019Article
- Virus RNA Load in Patients with Tick-Borne Encephalitis, Slovenia.Emerging infectious diseases · 2018Article
- Impact of pre-existing treatment with statins on the course and outcome of tick-borne encephalitis.PloS one · 2018Observational
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to quantify the severity of acute illness in patients with tick-borne encephalitis and to ascertain this approach by comparing it to standard clinical assessment. We designed scoring system for quantification of the severity of acute illness in patients with tick-borne encephalitis. Certain number of points was allotted to the presence, intensity, and duration of individual symptoms/signs. According to the obtained score the disease was classified as mild, moderate, and severe. Tick-borne encephalitis was assessed clinically as mild when only signs/symptoms of meningeal involvement were found, moderate in case of monofocal neurological signs and/or mild to moderate signs/symptoms of central nervous system dysfunction, and severe in patients with multifocal neurological signs and/or symptoms of severe dysfunction of central nervous system. By designed scoring system 282 adult patients, 146 males and 136 females, average aged 52.2 ± 15.5 years (range 15-82 years), with confirmed tick-borne encephalitis, were prospectively assessed. In 279/282 (98.9%) patients the severity according to clinical assessment matched with the score ranges for mild, moderate, and severe disease. The proposed approach enables precise and straightforward appraisal of the severity of acute illness and could be useful for comparison of findings within/between study groups.
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