SynthesisBioMed research international2014
The copper radioisotopes: a systematic review with special interest to 64Cu.
Synthesis in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 74 citations in OpenAlex.
- Article
- Design and development of a semi-automated solid target assembly for the indigenous production of medical radioisotopes in the PETrace-800 cyclotron.EJNMMI radiopharmacy and chemistry · 2026Article
- Multistep synthesis of a novel copper complex with potential for Alzheimer's disease diagnosis.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2023Article
- The Chemical Scaffold of Theranostic Radiopharmaceuticals: Radionuclide, Bifunctional Chelator, and Pharmacokinetics Modifying Linker.Molecules (Basel, Switzerland) · 2022Review
- Radiolabeled nanomaterials for biomedical applications: radiopharmacy in the era of nanotechnology.EJNMMI radiopharmacy and chemistry · 2022Review
- A New Preclinical Decision Support System Based on PET Radiomics: A Preliminary Study on the Evaluation of an InnovativeJournal of imaging · 2022Article
- Preclinical PET imaging study of lung cancer withAnnals of nuclear medicine · 2020Article
- Biological Applications of Thiocarbohydrazones and Their Metal Complexes: A Perspective Review.Pharmaceuticals (Basel, Switzerland) · 2019Review
- Preparation of Zirconium-89 Solutions for Radiopharmaceutical Purposes: Interrelation Between Formulation, Radiochemical Purity, Stability and Biodistribution.Molecules (Basel, Switzerland) · 2019Article
- Review
- Radiobiological Characterization ofMolecules (Basel, Switzerland) · 2018Article
- Porphyrins as ligands forMedChemComm · 2018Review
- PET radiometals for antibody labeling.Journal of labelled compounds & radiopharmaceuticals · 2018Review
- Synthesis, Radiolabelling and In Vitro Imaging of Multifunctional Nanoceramics.ChemNanoMat : chemistry of nanomaterials for energy, biology and more · 2018Article
- Retracted: The Copper Radioisotopes: A Systematic Review with Special Interest toBioMed research international · 2018Article
- The role of radionuclide probes for monitoring anti-tumor drugs efficacy: A brief review.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2017Review
- Determination of photon emission probability for the main gamma ray and half-life measurements ofApplied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2017Article
- Multimodality Imaging in Tumor Angiogenesis: Present Status and Perspectives.International journal of molecular sciences · 2017Review
- Radiolabeled bombesin derivatives for preclinical oncological imaging.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2017Review
- Somatostatin analogues labeled with copper radioisotopes: current status.Journal of radioanalytical and nuclear chemistry · 2017Review
Corrections and comments
- Retraction · 2018-07-08Euphemisms for Plagiarism · Plagiarism of/in Article ·
- Retracted
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Copper (Cu) is an important trace element in humans; it plays a role as a cofactor for numerous enzymes and other proteins crucial for respiration, iron transport, metabolism, cell growth, and hemostasis. Natural copper comprises two stable isotopes, (63)Cu and (65)Cu, and 5 principal radioisotopes for molecular imaging applications ((60)Cu, (61)Cu, (62)Cu, and (64)Cu) and in vivo targeted radiation therapy ((64)Cu and (67)Cu). The two potential ways to produce Cu radioisotopes concern the use of the cyclotron or the reactor. A noncopper target is used to produce noncarrier-added Cu thanks to a chemical separation from the target material using ion exchange chromatography achieving a high amount of radioactivity with the lowest possible amount of nonradioactive isotopes. In recent years, Cu isotopes have been linked to antibodies, proteins, peptides, and nanoparticles for preclinical and clinical research; pathological conditions that influence Cu metabolism such as Menkes syndrome, Wilson disease, inflammation, tumor growth, metastasis, angiogenesis, and drug resistance have been studied. We aim to discuss all Cu radioisotopes application focusing on (64)Cu and in particular its form (64)CuCl2 that seems to be the most promising for its half-life, radiation emissions, and stability with chelators, allowing several applications in oncological and nononcological fields.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.