Evidence map›Paper›PMID 24895580›Full record

ArticleBioMed research international2014

Mutation analysis of JAK2V617F, FLT3-ITD, NPM1, and DNMT3A in Chinese patients with myeloproliferative neoplasms.

Min Wang, Na He, Tian Tian, Lu Liu, Shuang Yu, Daoxin Ma

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. The Molecular Genetics of Myeloproliferative Neoplasms.Cold Spring Harbor perspectives in medicine · 2020
    Review
  5. Marked Thrombocytosis and Megakaryocytic Dysplasia in NPM1 Mutated De-Novo Acute Myeloid Leukemia.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Min WangDepartment of Hematology, Qilu Hospital, Shandong University, 107 West Wenhua Road, Jinan 250012, China.
Na HeDepartment of Hematology, Qilu Hospital, Shandong University, 107 West Wenhua Road, Jinan 250012, China.
Tian TianDepartment of Hematology, Qilu Hospital, Shandong University, 107 West Wenhua Road, Jinan 250012, China.
Lu LiuDepartment of Hematology, Qilu Hospital, Shandong University, 107 West Wenhua Road, Jinan 250012, China.
Shuang YuDepartment of Hematology, Qilu Hospital, Shandong University, 107 West Wenhua Road, Jinan 250012, China.
Daoxin MaDepartment of Hematology, Qilu Hospital, Shandong University, 107 West Wenhua Road, Jinan 250012, China.
Qilu Hospital of Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the discovery of JAK2V617F tyrosine kinase-activating mutation, several genes have been found mutated in myeloproliferative neoplasms (MPNs). FLT3-ITD, NPM1, and DNMT3A mutations frequently occurred in AML patients and have been found conferred with myeloproliferative neoplasms in mouse model. Therefore, we sought to search for mutations in JAK2V617F, FLT3-ITD, NPM1, and DNMT3A in 129 cases including 120 classic MPN cases and 9 MDS/MPN cases. JAK2V617F mutation was found in 60% of the 120 classic MPNs. However, none of the patients displayed FLT3-ITD and NPM1 mutations; only 2 patients harbored DNMT3A R882 mutation. Further studies including whole-genome sequence will be conducted to investigate the possible involvement of these genes in MPN.

Indexed as

AdultAgedAsian PeopleChinaDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNA Modification MethylasesDNA Mutational AnalysisFemalefms-Like Tyrosine Kinase 3HumansJanus Kinase 2MaleMiddle AgedMutationMyeloproliferative DisordersDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNA Modification MethylasesDNMT3A protein, humanDnmt3a protein, mouseFLT3 protein, humanfms-Like Tyrosine Kinase 3JAK2 protein, humanJanus Kinase 2NPM1 protein, humanNpm1 protein, mouseNuclear ProteinsNucleophosmin

Identifiers

PMID24895580
PMCPMC4034537
OpenAlexW2047857397

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.