ArticleDisease markers2014
Beta2-microglobulin as a diagnostic marker in cerebrospinal fluid: a follow-up study.
Article in Disease markers, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
- Cognitive impairment and CSF proteome modification after oral bacteriotherapy in HIV patients.Journal of neurovirology · 2020Trial
- Biomarkers of Lyme neuroborreliosis: a systematic review.Infection · 2026Review
- Subacute parkinsonism associated with proteinuria, hematuria, and PR3-ANCA positivity: a diagnostic challenge.BMC neurology · 2026Article
- Cerebrospinal fluid β2-microglobulin as a diagnostic biomarker in central nervous system lymphoma: a single-center retrospective analysis.Annals of hematology · 2025Article
- Neuronal MHC-I complex is destabilized by amyloid-β and its implications in Alzheimer's disease.Cell & bioscience · 2023Article
- CSF neopterin and beta-2-microglobulin as inflammation biomarkers in newborns with hypoxic-ischemic encephalopathy.Pediatric research · 2023Article
- β2-microglobulin is overexpressed in buccal cells of elderly and correlated with expression of p16 and inflammatory genes.Saudi journal of biological sciences · 2022Article
- Elevated cerebrospinal fluid levels of beta-2-microglobulin in patients with Guillain-Barré syndrome and their correlations with clinical features.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Single Cell Transcriptome Analysis of Niemann-Pick Disease, Type C1 Cerebella.International journal of molecular sciences · 2020Article
- Novel methods to diagnose leptomeningeal metastases in breast cancer.Neuro-oncology · 2019Review
- Role of beta-2-microglobulin as a biomarker in very preterm and extremely preterm infants with CNS inflammation.PloS one · 2019Article
- HIV-1-Associated Neurocognitive Disorders: Is HLA-C Binding Stability to βFrontiers in neurology · 2018Article
- A dual-label time-resolved fluorescence immunoassay for the simultaneous determination of ferritin and βJournal of clinical laboratory analysis · 2017Article
- Evidence for a Role of Nerve Injury in Painful Intervertebral Disc Degeneration: A Cross-Sectional Proteomic Analysis of Human Cerebrospinal Fluid.The journal of pain · 2017Article
- Article
- Clear differences in cerebrospinal fluid proteome between women with chronic widespread pain and healthy women - a multivariate explorative cross-sectional study.Journal of pain research · 2017Article
- The Implication and Significance of Beta 2 Microglobulin: A Conservative Multifunctional Regulator.Chinese medical journal · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Beta2-Microglobulin ( β 2-m) is a low molecular weight protein occurring in all body fluids. Its concentration increases in various pathologies. Increased values in cerebrospinal fluid (CSF) are ascribed to an activation of immune system. Using immunoturbidimetry, we examined concentrations of beta2-microglobulin in cerebrospinal fluid in a large group of 6274 patients with defined neurological diseases. Cell counts, total protein, albumin, glucose, lactic acid, immunoglobulins concentrations, and isofocusing (IEF) were also evaluated. We found substantial changes of CSF β 2-m concentrations in purulent meningitis, leptomeningeal metastasis, viral meningitis/encephalitis, and neuroborreliosis, while in multiple sclerosis these changes were not significant. Intrathecal synthesis and immune activation were present in these clinical entities. A new normative study enables better understanding of beta2-microglobulin behavior in CSF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.