ReviewClinical cardiology2014
Primary malignancies of the heart and pericardium.
Review in Clinical cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Prevalence of primary cardiac tumor malignancies in retrospective studies over six decades: a systematic review and meta-analysis.Oncotarget · 2017Pooled it
- Electrocardiographic manifestations and targeted management of cardiac complications in cardiac-involved DLBCL: a retrospective case series.Cardio-oncology (London, England) · 2025Article
- Primary cardiac lymphoma presenting double obstruction of the right ventricle.Journal of cardiology cases · 2025Article
- Rare Presentation of a Primary Cardiac Mass: Insights Into Multimodal Imaging, Histopathology, and Surgical Management.JACC. Case reports · 2025Article
- A Dynamic Multimodality Imaging Assessment of Right Ventricular Thrombosis in a Middle-Aged Man with Lymphocytic Interstitial Pneumonia: The Additive Role of Tissue Doppler Imaging.Journal of clinical medicine · 2025Article
- Primary Cardiac Myxofibrosarcoma of the Left Atrium with Heterologous Elements Mimicking a Cardiac Myxoma.The American journal of case reports · 2025Article
- Pericardial Disease in Patients with Cancer: Clinical Insights on Diagnosis and Treatment.Cancers · 2024Review
- Incidental cardiac lymphangioma misdiagnosed as atrial thrombus: A case report.Radiology case reports · 2024Article
- Reduced Risk of All-Cause, Cancer-, and Cardiovascular Disease-Related Mortality among Patients with Primary Malignant Cardiac Tumors Receiving Chemotherapy in the United States.Current oncology (Toronto, Ont.) · 2023Article
- Age and treatment disparities in survival of primary malignant cardiac tumors: an analysis of over 40 years and 500 patients.Journal of thoracic disease · 2023Article
- A mimicker of constriction: a case report of a rare case of cardiac angiosarcoma.European heart journal. Case reports · 2023Article
- Primary Cardiac Lymphoma Arising from Both Sides of the Heart.Internal medicine (Tokyo, Japan) · 2022Article
- A Case of Isolated Cardiac Burkitt Lymphoma Causing Right-Sided Heart Failure.Texas Heart Institute journal · 2022Article
- Case Report: Left atrial myxoma with confirmed Delta variant COVID-19 infection, "to treat or withhold".F1000Research · 2022Article
- Racial and ethnic characteristics and cancer-specific survival in Primary Malignant Cardiac Tumors.Frontiers in cardiovascular medicine · 2022Article
- Cardiac Sarcoma Presenting as Tamponade.Journal of community hospital internal medicine perspectives · 2022Article
- Cardiogenic shock among cancer patients.Frontiers in cardiovascular medicine · 2022Review
- Outcomes after resection of primary cardiac sarcoma.JTCVS open · 2021Article
- Surgical treatment for improved 1-year survival in patients with primary cardiac sarcoma.Anatolian journal of cardiology · 2021Article
- Development and validation of a nomogram prediction model for early mortality in patients with primary malignant cardiac tumors.Annals of translational medicine · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary malignancies of the heart and pericardium are rare. All the available data come from autopsy studies, case reports, and, in recent years, from large, specialized, single-center studies. Nevertheless, if primary malignancy is present, it may have a devastating implication for patients. Malignancies may affect heart function, also causing left-sided or right-sided heart failure. In addition, they can be responsible for embolic events or arrhythmias. Today, with the widespread use of noninvasive imaging modalities, heart tumors become evident, even as an incidental finding. A multimodality imaging approach is usually required to establish the final diagnosis. Despite the increased awareness and improved diagnostic techniques, clinical manifestations of primary malignancy of the heart and pericardium are so variable that their occurrence may still come as a surprise during surgery or autopsy. No randomized clinical trials have been carried out to determine the optimal therapy for these primary malignancies. Surgery is performed for small tumors. Chemotherapy and radiation therapy can be of help. Partial resection of large neoplasms is performed to relieve mechanical effects, such as cardiac compression or hemodynamic obstruction. Most patients present with marginally resectable or technically nonresectable disease at the time of diagnosis. It seems that orthotopic cardiac transplantation with subsequent immunosuppressive therapy may represent an option for very carefully selected patients. Early diagnosis and radical exeresis are of great importance for long-term survival of a primary cardiac malignancy. This can rarely be accomplished, and overall results are very disappointing.
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