Evidence map›Paper›PMID 24895270›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2015

GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China.

Yi Zeng, Huashuai Chen, Ting Ni, Rongping Ruan, Lei Feng, Chao Nie, Lingguo Cheng, Yang Li, Wei Tao, Jun Gu and 11 more

Open access · bronzeAbstract readComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.5field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 43 citations in OpenAlex.

  1. Trends in the prevalence of cognitive impairment at old age in China, 2002-2018.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
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  5. Allelic distribution ofAging medicine (Milton (N.S.W)) · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 10 institutions in 6 countries.

Yi ZengCenter for the Study of Aging and Human Development and Geriatrics Division, Medical School of Duke University, Durham, North Carolina. Center for Healthy Aging and Development Studies, National School of Development, Peking University, Beijing, China.
Huashuai ChenCenter for the Study of Aging and Human Development and Geriatrics Division, Medical School of Duke University, Durham, North Carolina. Business School of Xiangtan University, Hunan, China.
Ting NiState Key Laboratory of Genetics Engineering & MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.
Rongping RuanRenmin University of China, Beijing, China.
Lei FengNational University of Singapore.
Chao NieBGI-Shenzhen, China.
Lingguo ChengSchool of Business, Nanjing University, China.
Yang LiDepartment of Human Population Genetics, Institute of Molecular Medicine, Peking University, Beijing, China.
Wei TaoSchool of Life Sciences, Peking University, Beijing, China.
Jun GuSchool of Life Sciences, Peking University, Beijing, China.
Kenneth C LandPopulation Research Institute, Duke University, Durham, North Carolina.
Anatoli YashinPopulation Research Institute, Duke University, Durham, North Carolina.
Qihua TanUnit of Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense.
Ze YangNational Institute of Geriatrics, Beijing Hospital, Ministry of Health of China, Beijing, China.
Lars BolundBGI-Shenzhen, China. Department of Biomedicine, Aarhus University, Denmark.
Huanming YangBGI-Shenzhen, China. James D. Watson Institute of Genome Sciences, Hangzhou, China. Princess Al-Jawhara Centre of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia.
Elizabeth HauserCenter for Human Genetics, Medical Center, Duke University, Durham, North Carolina.
D Craig WillcoxDepartment of Human Welfare, Okinawa International University, Ginowan, Japan. Department of Research, Kuakini Medical Center and Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu.
Bradley J WillcoxDepartment of Research, Kuakini Medical Center and Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu.
Xiao-Li TianDepartment of Human Population Genetics, Institute of Molecular Medicine, Peking University, Beijing, China.
James W VaupelMax Planck Institute for Demographic Research, Rostock, Germany.
Peking University · CNBGI Group (China) · CNDuke University · USBeijing Hospital · CNMax Planck Institute for Demographic Research · DENanjing University · CNNational University of Singapore · SGOkinawa International University · JPRenmin University of China · CNState Key Laboratory of Genetic Engineering

Funding

Resource Core 3 - Metabolomics CoreP30AG028716 · NIA · DUKE UNIVERSITY · PI Virginia B Kraus · 2006 to 2026
$24.6M
STALLARD Admin Supp: Predicting Future Care Needs and Costs for Individual Medicare Enrollees with Incident Suspected Alzheimer's DiseaseP30AG034424 · NIA · DUKE UNIVERSITY · PI SCOTT M. LYNCH · 2009 to 2026
$12.2M
FOXO3 Genotype, InflammAging, Cardiovascular Disease, and Dementia. Kuakini Hawaii Lifespan Study III. Administrative Supplement.R01AG027060 · NIA · KUAKINI MEDICAL CENTER · PI Gregory J. Tranah, BRADLEY JOHN WILLCOX · 2005 to 2026
$8.1M
Demographic Analysis on Determinants of Healthy Longevity in ChinaR01AG023627 · NIA · DUKE UNIVERSITY · PI ZENG, YI · 2004 to 2014
$3.9M
Energy-sensing Pathways, Healthy Aging and LongevityR01AG038707 · NIA · KUAKINI MEDICAL CENTER · PI WILLCOX, BRADLEY JOHN · 2011 to 2014
$1.4M
NIA NIH HHS P30 AG028716NIA NIH HHS P30AG028716NIA NIH HHS P30 AG034424NIA NIH HHS R01 AG023627NIA NIH HHS R01 AG027060NIA NIH HHS R01AG027060NIA NIH HHS R01 AG038707NIA NIH HHS R01AG038707
6 · The paper itself

Abstract

Logistic regression analysis based on data from 822 Han Chinese oldest old aged 92+ demonstrated that interactions between carrying FOXO1A-266 or FOXO3-310 or FOXO3-292 and tea drinking at around age 60 or at present time were significantly associated with lower risk of cognitive disability at advanced ages. Associations between tea drinking and reduced cognitive disability were much stronger among carriers of the genotypes of FOXO1A-266 or FOXO3-310 or FOXO3-292 compared with noncarriers, and it was reconfirmed by analysis of three-way interactions across FOXO genotypes, tea drinking at around age 60, and at present time. Based on prior findings from animal and human cell models, we postulate that intake of tea compounds may activate FOXO gene expression, which in turn may positively affect cognitive function in the oldest old population. Our empirical findings imply that the health benefits of particular nutritional interventions, including tea drinking, may, in part, depend upon individual genetic profiles.

Indexed as

Drinking BehaviorTeaAged, 80 and overAgingAllelesAsian PeopleChinaCognitionCognition DisordersEvidence-Based MedicineFemaleForkhead Box Protein O1Forkhead Box Protein O3Forkhead Transcription FactorsGene ExpressionGenotypeForkhead Box Protein O1Forkhead Box Protein O3Forkhead Transcription FactorsFOXO1 protein, humanFOXO3 protein, humanTeaCognitive disabilityFOXO genotypesGxE interactionsOldest old.Tea drinking

Identifiers

PMID24895270
PMCPMC4447795
OpenAlexW1993002454

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.