ArticleMuscle & nerve2015
Wallerian degeneration and recovery of motor nerves after multiple focused cold therapies.
Article in Muscle & nerve, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05674604 (Cryoneurolysis as a Drug Free Novel Treatment for Knee and Shoulder Pain Impairing Inpatient Neurological Rehabilitation), which is not on this map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cryoneurolysis as a Drug Free Novel Treatment for Knee and Shoulder Pain Impairing Inpatient Neurological Rehabilitation
Who cites it
41 citing papers in PubMed, 91 citations in OpenAlex.
- Sequential Cryoneurolysis and Percutaneous Needle Tenotomy for Refractory Wrist Flexor Contracture: A Retrospective Case Series in Stroke and Spinal Cord Injury.Archives of rehabilitation research and clinical translation · 2026Article
- Cryoneurolysis for Spasticity in a Pediatric Patient With Cold Urticaria Managed With Targeted Skin Warming: A Case Report.Archives of rehabilitation research and clinical translation · 2026Article
- Posterior Single-Window Ultrasound-Guided Cryoneurolysis for Severe Pediatric Spastic Equinovarus: Technical Feasibility and Same-Patient Comparison.Reports (MDPI) · 2026Article
- Percutaneous Cryoneurolysis for Upper Limb Spasticity: A Systematic Scoping Review of Current Evidence, Safety Profile, and Implications for Hand and Upper Extremity Practice.Journal of clinical medicine · 2026Review
- Cryoneurolysis for the management of pain secondary to obstetrical brachial plexus injury: a case report.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2026Article
- Preoperative Cryoneurolysis in Total Knee Arthroplasty: Current Concepts in Pain Control and Opioid Stewardship.Cureus · 2026Review
- Emerging Nonpharmacologic Analgesic Technologies in Anesthesia: Mechanisms, Evidence, and Future Directions for Pharmacologic Alternatives.Biomedicines · 2026Review
- Targeted and Sequential Cryoneurolysis Improves Gait After Botulinum-Toxin Unresponsiveness in Post-Stroke Spasticity: A Laboratory-Verified Case.Neurology international · 2026Article
- Use of Cryoneurolysis Therapy for the Management of Idiopathic Trigeminal Neuralgia.Orthopedic reviews · 2026Article
- The Safety and Tolerability of a Single Scleral Treatment With a Cooling Device in Rabbits.Translational vision science & technology · 2025Article
- Percutaneous Cryoneurolysis of Splanchnic Nerves for Pain Palliation in Patients with Pancreatic Cancer: A Single-Center Experience.Cardiovascular and interventional radiology · 2025Observational
- Interventional Radiology Management of Bone Metastasis Pain: Strategies and Techniques.Cardiovascular and interventional radiology · 2025Review
- One- versus Two-Minute Intercostal Nerve Cryoanalgesia in Children Undergoing Surgery for Funnel Chest Deformity.Journal of personalized medicine · 2024Article
- Cryoneurolysis for the Treatment of Knee Arthritis to Facilitate Inpatient Rehabilitation: A Case Report.Archives of rehabilitation research and clinical translation · 2024Article
- Applications of Cryoneurolysis in Chronic Pain Management: a Review of the Current Literature.Current pain and headache reports · 2024Review
- Cryoanalgesia as the Essential Element of Enhanced Recovery after Surgery (ERAS) in Children Undergoing Thoracic Surgery-Scoping Review.Journal of personalized medicine · 2024Article
- Cryoneurolysis of the Femoral Nerve for Focal Spasticity in an Ambulatory Patient.Archives of rehabilitation research and clinical translation · 2024Article
- Cementoplasty to cryoablation: review and current status.BJR open · 2024Review
- Benefits of the Erector Spinae Plane Block before Cryoanalgesia in Children Undergoing Surgery for Funnel Chest Deformity.Journal of personalized medicine · 2023Article
- Commentary on Selective Neurocoagulation of Gastrocnemius and Lateral Soleus Muscles for Calf Reduction.Aesthetic plastic surgery · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionA device has been developed to apply freezing temperatures to temporarily impede nerve conduction, resulting in inhibition of voluntary skeletal muscle contraction. This device was designed as an alternative to the neurotoxins usually used to treat movement disorders.
methodsWe evaluated the effects of single and 3 repeat treatments with a cryoprobe device (-55°C) on a sciatic nerve rat model. Long-term effects of repeated treatment were evaluated through assessments of physiological function and histological analysis.
resultsThere was consistent weakening of physiological function after each treatment, with recovery of normal function by 8 weeks posttreatment. Histological findings showed axonal degeneration with no disruption to the epineurial or perineurial structures. Progressive axonal regeneration was followed by normal recovery by 24 weeks post-treatment.
conclusionsLow-temperature treatment of motor nerves did not result in permanent or long-term changes to nerve function or structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.