Trial reportJournal of the American Heart Association2014
Postextrasystolic blood pressure potentiation predicts poor outcome of cardiac patients.
Trial report in Journal of the American Heart Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Autonomic Regulation Trial (ART)
Post-Extrasystolic Potentiation as a Predictor of Ventricular Arrhythmias
Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Calcium-mediated force-interval relationship drives post-extrasystolic potentiation in premature ventricular complexes: a computational study.Biomechanics and modeling in mechanobiology · 2026Article
- Post-extrasystolic variation of ST segment and T wave as a mortality risk predictor after myocardial infarction.Frontiers in physiology · 2024Article
- The Polyscore of autonomic parameters predicts mortality and identifies low-risk individuals among diabetic survivors of acute myocardial infarction.Scientific reports · 2022Article
- Polyscore of autonomic parameters for risk stratification of the elderly general population: the Polyscore study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2021Article
- Polyscore of Non-invasive Cardiac Risk Factors.Frontiers in physiology · 2019Article
- Clinical value of different QRS-T angle expressions.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2018Article
- An Augmented Negative Force-Frequency Relationship and Slowed Mechanical Restitution Are Associated With Increased Susceptibility to Drug-Induced Torsade de Pointes Arrhythmias in the Chronic Atrioventricular Block Dog.Frontiers in physiology · 2018Article
- Sex differences in long-term mortality among acute myocardial infarction patients: Results from the ISAR-RISK and ART studies.PloS one · 2017Article
- Post-extrasystolic Blood Pressure Potentiation as a Risk Predictor in Cardiac Patients.Arrhythmia & electrophysiology review · 2016Article
- Post-extrasystolic Potentiation: Link between Ca(2+) Homeostasis and Heart Failure?Arrhythmia & electrophysiology review · 2016Article
- The Cooperative Health Research in South Tyrol (CHRIS) study: rationale, objectives, and preliminary results.Journal of translational medicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundPostextrasystolic blood pressure potentiation (PESP), the pulse wave augmentation after an extrasystolic beat, is typically enhanced in heart failure (HF) patients. This study prospectively tested the association of PESP and mortality in cardiac patients. METHODS AND
resultsConsecutive patients (n=941; mean age, 61 years; 19% female) presenting with acute myocardial infarction were enrolled between May 2000 and March 2005 and followed up until August 2010. The main study outcome was 5-year all-cause mortality. Patients underwent noninvasive 30-minute recordings of ECG and continuous blood pressure. PESP presence was based on the ratio between the first postectopic pulse wave amplitude and the mean of the subsequent 9 pulse wave amplitudes. A ratio above 1 was prospectively defined as PESP present. Ventricular premature complexes (VPCs) suitable for PESP quantification were present in recordings of 220 patients. PESP was present in 62 of these patients. Patients without suitable VPCs were classified as PESP absent.During the follow-up, 72 patients died. Among the 220 patients in whom PESP was measurable, 27 died. Under univariable analysis, PESP was a significant predictor of death (P<0.001) as were GRACE score (P<0.001), left ventricular ejection fraction (LVEF) (P<0.001), and the number of recorded VPCs (P<0.001). Under multivariable analysis, PESP (P<0.001), GRACE score (P<0.001), and LVEF (P=0.001) were independently associated with outcome. The combination of PESP presence and LVEF ≤ 35% identified a subgroup of patients with a particularly high mortality of 46.7%. Separate validation reproduced the finding in an unrelated population of 146 HF patients.
conclusionsPESP, which likely reflects abnormalities of myocardial calcium cycling, predicts the mortality risk in postinfarction patients. CLINICAL TRIAL REGISTRATION URL: ClinicalTrials.gov. Unique identifier: NCT00196274.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.