ReviewImmunologic research2014
Purified monomeric ligand.MD-2 complexes reveal molecular and structural requirements for activation and antagonism of TLR4 by Gram-negative bacterial endotoxins.
Review in Immunologic research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Therapeutic Targeting of TLR4 for Inflammation, Infection, and Cancer: A Perspective for Disaccharide Lipid A Mimetics.Pharmaceuticals (Basel, Switzerland) · 2022Review
- New Insights on End-Stage Renal Disease and Healthy Individual Gut Bacterial Translocation: Different Carbon Composition of Lipopolysaccharides and Different Impact on Monocyte Inflammatory Response.Frontiers in immunology · 2021Article
- Biochemical transformation of bacterial lipopolysaccharides by acyloxyacyl hydrolase reduces host injury and promotes recovery.The Journal of biological chemistry · 2020Review
- An electrochemical sensor for bacterial lipopolysaccharide detection based on dual functional CuMikrochimica acta · 2020Article
- Escherichia coli adhesion portion FimH functions as an adjuvant for cancer immunotherapy.Nature communications · 2020Article
- Household endotoxin reduction in the Louisa Environmental Intervention Project for rural childhood asthma.Indoor air · 2020Article
- 5-Aza-2'-deoxycytidine enhances lipopolysaccharide-induced inflammatory cytokine expression in human dental pulp cells by regulating TRAF6 methylation.Bioengineered · 2019Article
- Detecting lipopolysaccharide in the cytosol of mammalian cells: Lessons from MD-2/TLR4.Journal of leukocyte biology · 2019Review
- Memory-Like Inflammatory Responses of Microglia to Rising Doses of LPS: Key Role of PI3Kγ.Frontiers in immunology · 2019Article
- Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design.Molecular therapy. Nucleic acids · 2018Article
- Diverse pro-inflammatory endotoxin recognition systems of mammalian innate immunity.F1000Research · 2018Review
- Coevolution of the Toll-Like Receptor 4 Complex with Calgranulins and Lipopolysaccharide.Frontiers in immunology · 2018Article
- High-affinity caspase-4 binding to LPS presented as high molecular mass aggregates or in outer membrane vesicles.Innate immunity · 2017Article
- Targeting myeloid differentiation protein 2 by the new chalcone L2H21 protects LPS-induced acute lung injury.Journal of cellular and molecular medicine · 2017Article
- Molecular Basis of the Functional Differences between Soluble Human Versus Murine MD-2: Role of Val135 in Transfer of Lipopolysaccharide from CD14 to MD-2.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Studies of the TLR4-associated protein MD-2 using yeast-display and mutational analyses.Molecular immunology · 2015Article
- Endotoxin Exposure: Predictors and Prevalence of Associated Asthma Outcomes in the United States.American journal of respiratory and critical care medicine · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
A major focus of work in our laboratory concerns the molecular mechanisms and structural bases of Gram-negative bacterial endotoxin recognition by host (e.g., human) endotoxin-recognition proteins that mediate and/or regulate activation of Toll-like receptor (TLR) 4. Here, we review studies of wild-type and variant monomeric endotoxin.MD-2 complexes first produced and characterized in our laboratories. These purified complexes have provided unique experimental reagents, revealing both quantitative and qualitative determinants of TLR4 activation and antagonism. This review is dedicated to the memory of Dr. Theresa L. Gioannini (1949-2014) who played a central role in many of the studies and discoveries that are reviewed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.